{"id":162150,"date":"2023-04-14T06:23:26","date_gmt":"2023-04-14T11:23:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/04\/reduced-editing-implicated-in-mitochondrial-cascade-of-schizophrenia-related-rna"},"modified":"2023-04-14T06:23:26","modified_gmt":"2023-04-14T11:23:26","slug":"reduced-editing-implicated-in-mitochondrial-cascade-of-schizophrenia-related-rna","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/04\/reduced-editing-implicated-in-mitochondrial-cascade-of-schizophrenia-related-rna","title":{"rendered":"Reduced editing implicated in mitochondrial cascade of schizophrenia related RNA"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/reduced-editing-implicated-in-mitochondrial-cascade-of-schizophrenia-related-rna2.jpg\"><\/a><\/p>\n<p>Researchers at the University of California at Los Angeles have analyzed RNA editing in postmortem brains of four schizophrenia cohorts and uncovered a significant and reproducible trend of hypo-editing in patients of European descent.<\/p>\n<p>The paper \u201cWidespread RNA hypo-editing in schizophrenia and its relevance to <a href=\"https:\/\/medicalxpress.com\/tags\/mitochondrial+function\/\" rel=\"tag\" class=\"\">mitochondrial function<\/a>,\u201d published in <i>Science Advances<\/i>, details the research team\u2019s efforts to isolate functionally impacting RNA editing sites to understand how dysregulated editing contributes to various disorders.<\/p>\n<p>In the data analysis, researchers identified 26,841 unique differential editing sites. They observed a significant trend of lower than expected amounts of RNA editing in the schizophrenia groups, which was reproduced in three of the four cohorts of European individuals.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the University of California at Los Angeles have analyzed RNA editing in postmortem brains of four schizophrenia cohorts and uncovered a significant and reproducible trend of hypo-editing in patients of European descent. The paper \u201cWidespread RNA hypo-editing in schizophrenia and its relevance to mitochondrial function,\u201d published in Science Advances, details the research team\u2019s [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-162150","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/162150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=162150"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/162150\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=162150"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=162150"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=162150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}