{"id":161852,"date":"2023-04-10T14:24:39","date_gmt":"2023-04-10T19:24:39","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/04\/research-uncovers-alternate-mechanism-for-producing-key-protein-in-metastatic-prostate-cancer"},"modified":"2023-04-10T14:24:39","modified_gmt":"2023-04-10T19:24:39","slug":"research-uncovers-alternate-mechanism-for-producing-key-protein-in-metastatic-prostate-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/04\/research-uncovers-alternate-mechanism-for-producing-key-protein-in-metastatic-prostate-cancer","title":{"rendered":"Research uncovers alternate mechanism for producing key protein in metastatic prostate cancer"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/research-uncovers-alternate-mechanism-for-producing-key-protein-in-metastatic-prostate-cancer2.jpg\"><\/a><\/p>\n<p>Like the better-known prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA) is a biomarker that can tell physicians much about a patient\u2019s metastatic prostate cancer. PSMA is a protein on the cell surface of most prostate cancers; scanning for it with positron emission tomography (PET) can indicate where in the body prostate cancer has spread, and it can be targeted with a newly approved radioactive therapy. In 15%\u201320% of patients with castration-resistant prostate cancer, however, PSMA production stops at advanced stages of the disease.<\/p>\n<p>In a new study in the journal <i>Nature Cancer<\/i>, Dana-Farber Cancer Institute scientists shed new light on the mechanism that raises and lowers PSMA expression in prostate cancer cells. The findings may help physicians select PSMA-targeting therapies for specific patients.<\/p>\n<p>It has long been known that the androgen receptor (AR)\u2014a structure that triggers <a href=\"https:\/\/medicalxpress.com\/tags\/cell+growth\/\" rel=\"tag\" class=\"\">cell growth<\/a> in response to the hormone androgen\u2014controls the production of PSMA in prostate cancer cells. In the <i>Nature Cancer<\/i> study, researchers led by Dana-Farber\u2019s Himisha Beltran, MD, and Martin Bakht, Ph.D., found that PSMA expression is lower in liver metastases than in other parts of the body, regardless of expression of the <a href=\"https:\/\/medicalxpress.com\/tags\/androgen+receptor\/\" rel=\"tag\" class=\"\">androgen receptor<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Like the better-known prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA) is a biomarker that can tell physicians much about a patient\u2019s metastatic prostate cancer. PSMA is a protein on the cell surface of most prostate cancers; scanning for it with positron emission tomography (PET) can indicate where in the body prostate cancer has spread, and [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1498,11],"tags":[],"class_list":["post-161852","post","type-post","status-publish","format-standard","hentry","category-augmented-reality","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/161852","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=161852"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/161852\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=161852"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=161852"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=161852"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}