{"id":161430,"date":"2023-04-02T00:22:59","date_gmt":"2023-04-02T05:22:59","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/04\/predicting-neuroblastoma-outcomes-with-molecular-evolution"},"modified":"2023-04-02T00:22:59","modified_gmt":"2023-04-02T05:22:59","slug":"predicting-neuroblastoma-outcomes-with-molecular-evolution","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/04\/predicting-neuroblastoma-outcomes-with-molecular-evolution","title":{"rendered":"Predicting neuroblastoma outcomes with molecular evolution"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/predicting-neuroblastoma-outcomes-with-molecular-evolution2.jpg\"><\/a><\/p>\n<p>A research team led by the German Cancer Research Center in Heidelberg, Germany, has discovered that the genetic sequence of a tumor can be read like a molecular clock, traced back to its most recent common ancestor cell. Extracting the duration of tumor evolution can give an accurate predictor of neuroblastoma outcomes.<\/p>\n<p>In a paper published in <i>Nature Genetics<\/i> titled \u201cNeuroblastoma arises in early fetal development and its evolutionary duration predicts outcome,\u201d the team details the steps they took in identifying a genomic clock tested against a <a href=\"https:\/\/medicalxpress.com\/tags\/whole+genome\/\" rel=\"tag\" class=\"\">whole genome<\/a> sequenced population combined with analysis and mathematical modeling, to identify evolution markers, traceability and a likely origin point of infant neuroblastomas.<\/p>\n<p>Cancer cells start out life as heroic healthy tissues, with the sort of all for one, one for all, throw yourself on a grenade to save your mates\u2013type attitude that is taking place throughout the body every day. At some point, something goes wrong, and a good cell goes bad.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A research team led by the German Cancer Research Center in Heidelberg, Germany, has discovered that the genetic sequence of a tumor can be read like a molecular clock, traced back to its most recent common ancestor cell. Extracting the duration of tumor evolution can give an accurate predictor of neuroblastoma outcomes. In a paper [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,385,412,2229],"tags":[],"class_list":["post-161430","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-evolution","category-genetics","category-mathematics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/161430","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=161430"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/161430\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=161430"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=161430"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=161430"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}