{"id":161428,"date":"2023-04-02T00:22:42","date_gmt":"2023-04-02T05:22:42","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/04\/first-single-molecule-microscopic-visualization-of-the-full-length-human-brca2-protein-binding-to-dna"},"modified":"2023-04-02T00:22:42","modified_gmt":"2023-04-02T05:22:42","slug":"first-single-molecule-microscopic-visualization-of-the-full-length-human-brca2-protein-binding-to-dna","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/04\/first-single-molecule-microscopic-visualization-of-the-full-length-human-brca2-protein-binding-to-dna","title":{"rendered":"First single molecule microscopic visualization of the full-length human BRCA2 protein binding to DNA"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/first-single-molecule-microscopic-visualization-of-the-full-length-human-brca2-protein-binding-to-dna2.jpg\"><\/a><\/p>\n<p>Using a self-built inverted microscope complete with laser optical tweezers to capture DNA, Yale Cancer Center and University of California Davis researchers for the first time created a visualization of the full-length human BRCA2 protein at the single molecule level.<\/p>\n<p>Mutations in the breast cancer susceptibility gene, BRCA2, can significantly increase an individual\u2019s lifetime risk of developing cancer. Approximately one in every 400 people carry a BRCA gene mutation accounting for a significant proportion of cancer that is heritable. The study was published on March 28 in the Proceedings of the National Academy of Sciences.<\/p>\n<p>\u201cIf you carry a BRCA mutation, you have this incredibly high risk for breast and <a href=\"https:\/\/medicalxpress.com\/tags\/ovarian+cancer\/\" rel=\"tag\" class=\"\">ovarian cancer<\/a>, and also for men, prostate and <a href=\"https:\/\/medicalxpress.com\/tags\/pancreatic+cancer\/\" rel=\"tag\" class=\"\">pancreatic cancer<\/a>,\u201d said Yale Cancer Center member and co-author of the paper, Ryan Jensen, Ph.D., who is also an associate professor of therapeutic Radiology at Yale School of Medicine.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Using a self-built inverted microscope complete with laser optical tweezers to capture DNA, Yale Cancer Center and University of California Davis researchers for the first time created a visualization of the full-length human BRCA2 protein at the single molecule level. Mutations in the breast cancer susceptibility gene, BRCA2, can significantly increase an individual\u2019s lifetime risk [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-161428","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/161428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=161428"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/161428\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=161428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=161428"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=161428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}