{"id":159992,"date":"2023-03-10T17:22:18","date_gmt":"2023-03-10T23:22:18","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/03\/metformin-and-rapamycin-rejuvenate-stem-cells-in-mice"},"modified":"2023-03-10T17:22:18","modified_gmt":"2023-03-10T23:22:18","slug":"metformin-and-rapamycin-rejuvenate-stem-cells-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/03\/metformin-and-rapamycin-rejuvenate-stem-cells-in-mice","title":{"rendered":"Metformin and Rapamycin Rejuvenate Stem Cells in Mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/metformin-and-rapamycin-rejuvenate-stem-cells-in-mice2.jpg\"><\/a><\/p>\n<p>Recently is has become known that one should not take Metformin unless you have diabetes. But a combo test of Rapamycin and Metformin showed each removed each others side effects. So here we have another combo test showing the effect on stem cells in the gut.<\/p>\n<hr>\n<p>In a new study published in <i>Aging Cell<\/i>, researchers have shown that two promising anti-aging agents, the antibiotic rapamycin and the anti-diabetic drug metformin, <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.13802\">reverse aging in a population of intestinal stem cells<\/a> [1].<\/p>\n<p>Older people are more prone to gastrointestinal problems [2]. Moreover, aging is a major risk factor for various cancers, including colorectal cancer. Therefore, it is necessary to develop therapeutic approaches to rejuvenate the aging intestine.<\/p>\n<p>The function and structure of the intestinal epithelium, a single cell layer that lines the small intestine and colon, is maintained by the residing stem cells. Intestinal stem cells continuously divide to generate several types of progenitor cells.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Recently is has become known that one should not take Metformin unless you have diabetes. But a combo test of Rapamycin and Metformin showed each removed each others side effects. So here we have another combo test showing the effect on stem cells in the gut. In a new study published in Aging Cell, researchers [\u2026]<\/p>\n","protected":false},"author":388,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-159992","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/159992","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/388"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=159992"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/159992\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=159992"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=159992"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=159992"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}