{"id":159797,"date":"2023-03-08T01:23:17","date_gmt":"2023-03-08T07:23:17","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/03\/modifying-messenger-rna-may-provide-a-new-target-for-alzheimers-disease"},"modified":"2023-03-08T01:23:17","modified_gmt":"2023-03-08T07:23:17","slug":"modifying-messenger-rna-may-provide-a-new-target-for-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/03\/modifying-messenger-rna-may-provide-a-new-target-for-alzheimers-disease","title":{"rendered":"Modifying messenger RNA may provide a new target for Alzheimer\u2019s disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/modifying-messenger-rna-may-provide-a-new-target-for-alzheimers-disease2.jpg\"><\/a><\/p>\n<p>Reducing the methylation of a key messenger RNA can promote migration of macrophages into the brain and ameliorate symptoms of Alzheimer\u2019s disease in a mouse model, according to a new study publishing March 7 in the open access journal <i>PLOS Biology<\/i> by Rui Zhang of Air Force Medical University in Xian, Shaanxi, China. The results illuminate one pathway for entrance of peripheral immune cells into the brain, and may provide a new target for treatment of Alzheimer\u2019s disease.<\/p>\n<p>A presumed trigger for the development of Alzheimer\u2019s disease is the accumulation of proteinaceous, extracellular amyloid-beta plaques in the brain. High levels of amyloid-beta in mice leads to neurodegeneration and cognitive symptoms reminiscent of human Alzheimer\u2019s disease, and reduction of amyloid-beta is a major goal in development of new treatments.<\/p>\n<p>One potential pathway for getting rid of amyloid-beta is the <a href=\"https:\/\/medicalxpress.com\/tags\/migration\/\" rel=\"tag\" class=\"\">migration<\/a> of blood-derived <a href=\"https:\/\/medicalxpress.com\/tags\/myeloid+cells\/\" rel=\"tag\" class=\"\">myeloid cells<\/a> into the brain, and their maturation into macrophages, which, along with resident microglia, can consume amyloid-beta. That migration is a complex phenomenon controlled by multiple interacting players, but a potentially important one is the methylation of messenger RNA within the <a href=\"https:\/\/medicalxpress.com\/tags\/myeloid\/\" rel=\"tag\" class=\"\">myeloid<\/a> cells.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Reducing the methylation of a key messenger RNA can promote migration of macrophages into the brain and ameliorate symptoms of Alzheimer\u2019s disease in a mouse model, according to a new study publishing March 7 in the open access journal PLOS Biology by Rui Zhang of Air Force Medical University in Xian, Shaanxi, China. The results [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-159797","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/159797","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=159797"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/159797\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=159797"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=159797"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=159797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}