{"id":15867,"date":"2015-08-03T17:47:01","date_gmt":"2015-08-04T00:47:01","guid":{"rendered":"http:\/\/lifeboat.com\/blog\/2015\/08\/getting-to-the-bottom-of-aging"},"modified":"2017-06-04T11:50:32","modified_gmt":"2017-06-04T18:50:32","slug":"getting-to-the-bottom-of-aging","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2015\/08\/getting-to-the-bottom-of-aging","title":{"rendered":"Getting to the bottom of aging"},"content":{"rendered":"<p><a class=\\'blog-photo\\' href=\"https:\/\/lifeboat.com\/blog.images\/getting-to-the-bottom-of-aging.jpg\"><\/a><\/p>\n<p>August 3, 2015 The question of why we age is one of the most fascinating questions for humankind, but nothing close to a satisfactory answer has been found to date. Scientists at the Leibniz-Institut f\u00fcr Molekulare Pharmakologie in Berlin have now shown, for the first time, that the ER loses its oxidative power in advanced age, which shifts the reducing\/oxidising equilibrium \u2014 redox for short \u2014 in this compartment. This leads to a decline in the capacity to form the disulphide bridges that are so important for correct protein folding. As a consequence, many proteins can no longer mature properly and become unstable.<\/p>\n<p><a href=\"http:\/\/scienceofsingularity.com\/2015\/08\/03\/getting-to-the-bottom-of-aging\/\" target=\"_blank\">Read more<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>August 3, 2015 The question of why we age is one of the most fascinating questions for humankind, but nothing close to a satisfactory answer has been found to date. Scientists at the Leibniz-Institut f\u00fcr Molekulare Pharmakologie in Berlin have now shown, for the first time, that the ER loses its oxidative power in advanced [\u2026]<\/p>\n","protected":false},"author":374,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269],"tags":[],"class_list":["post-15867","post","type-post","status-publish","format-standard","hentry","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/15867","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/374"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=15867"}],"version-history":[{"count":2,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/15867\/revisions"}],"predecessor-version":[{"id":64503,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/15867\/revisions\/64503"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=15867"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=15867"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=15867"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}