{"id":157883,"date":"2023-02-13T16:23:58","date_gmt":"2023-02-13T22:23:58","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/02\/high-dose-intravenous-vitamin-c-treatment-in-sepsis-associations-with-acute-kidney-injury-and-mortality"},"modified":"2023-02-13T16:23:58","modified_gmt":"2023-02-13T22:23:58","slug":"high-dose-intravenous-vitamin-c-treatment-in-sepsis-associations-with-acute-kidney-injury-and-mortality","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/02\/high-dose-intravenous-vitamin-c-treatment-in-sepsis-associations-with-acute-kidney-injury-and-mortality","title":{"rendered":"High dose intravenous vitamin C treatment in Sepsis: associations with acute kidney injury and mortality"},"content":{"rendered":"<p><a class=\"blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/high-dose-intravenous-vitamin-c-treatment-in-sepsis-associations-with-acute-kidney-injury-and-mortality2.jpg\"><\/a><\/p>\n<p>The effects of vitamin C on clinical outcomes in critically ill patients remain controversial due to inconclusive studies. This retrospective observational cohort study evaluated the effects of vitamin C therapy on acute kidney injury (AKI) and mortality among septic patients.<\/p>\n<p>Electronic medical records of 1,390 patients from an academic hospital who were categorized as Treatment (received at least one dose of 1.5 g IV vitamin C, <i>n<\/i> = 212) or Comparison (received no, or less than 1.5 g IV vitamin C, <i>n<\/i> = 1178) were reviewed. Propensity score matching was conducted to balance a number of covariates between groups. Multivariate logistic regressions were conducted predicting AKI and in-hospital mortality among the full sample and a sub-sample of patients seen in the ICU.<\/p>\n<p>Data revealed that vitamin C therapy was associated with <i>increase<\/i>s in AKI (OR = 2.07 95% CI [1.46\u20132.93]) and in-hospital mortality (OR = 1.67 95% CI [1.003\u20132.78]) after adjusting for demographic and clinical covariates. When stratified to examine ICU patients, vitamin C therapy remained a significant risk factor of AKI (OR = 1.61 95% CI [1.09\u20132.39]) and provided no protective benefit against mortality (OR = 0.79 95% CI [0.48\u20131.31]).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The effects of vitamin C on clinical outcomes in critically ill patients remain controversial due to inconclusive studies. This retrospective observational cohort study evaluated the effects of vitamin C therapy on acute kidney injury (AKI) and mortality among septic patients. Electronic medical records of 1,390 patients from an academic hospital who were categorized as Treatment [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-157883","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/157883","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=157883"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/157883\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=157883"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=157883"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=157883"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}