{"id":156978,"date":"2023-02-03T23:22:19","date_gmt":"2023-02-04T05:22:19","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/02\/this-one-atom-chemical-reaction-could-transform-drug-discovery"},"modified":"2023-02-03T23:22:19","modified_gmt":"2023-02-04T05:22:19","slug":"this-one-atom-chemical-reaction-could-transform-drug-discovery","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/02\/this-one-atom-chemical-reaction-could-transform-drug-discovery","title":{"rendered":"This one-atom chemical reaction could transform drug discovery"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/this-one-atom-chemical-reaction-could-transform-drug-discovery3.jpg\"><\/a><\/p>\n<p>Pharmaceutical synthesis is often quite complex; simplifications are needed to speed up the initial phase of drug development and lower the cost of generic production. Now, in a study recently published in <i>Science<\/i>, researchers from Osaka University have discovered a chemical reaction that could transform drug production because of its simplicity and utility.<\/p>\n<p>Pharmaceuticals generally contain a few tens of atoms and a similar number of chemical bonds between the atoms. Thus, designing complex <a href=\"https:\/\/phys.org\/tags\/drug\/\" rel=\"tag\" class=\"\">drug<\/a> architectures from simple precursors using the techniques of <a href=\"https:\/\/phys.org\/tags\/organic+chemistry\/\" rel=\"tag\" class=\"\">organic chemistry<\/a> usually requires careful planning and tedious, incremental steps.<\/p>\n<p>The gold standard in drug synthesis is to create, in one step, as many chemical bonds as possible. In principle, adding one <a href=\"https:\/\/phys.org\/tags\/carbon\/\" rel=\"tag\" class=\"\">carbon<\/a> atom\u2014by forming four bonds in one step\u2014to a drug precursor can be a means of doing so. Unfortunately, atomic carbon is generally too unstable for use in common chemical reaction conditions. This is the problem that the researchers sought to address.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pharmaceutical synthesis is often quite complex; simplifications are needed to speed up the initial phase of drug development and lower the cost of generic production. Now, in a study recently published in Science, researchers from Osaka University have discovered a chemical reaction that could transform drug production because of its simplicity and utility. Pharmaceuticals generally [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19],"tags":[],"class_list":["post-156978","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/156978","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=156978"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/156978\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=156978"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=156978"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=156978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}