{"id":156353,"date":"2023-01-26T19:28:05","date_gmt":"2023-01-27T01:28:05","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/01\/twelve-hour-rhythms-in-transcript-expression-within-the-human-dorsolateral-prefrontal-cortex-are-altered-in-schizophrenia"},"modified":"2023-01-26T19:28:05","modified_gmt":"2023-01-27T01:28:05","slug":"twelve-hour-rhythms-in-transcript-expression-within-the-human-dorsolateral-prefrontal-cortex-are-altered-in-schizophrenia","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/01\/twelve-hour-rhythms-in-transcript-expression-within-the-human-dorsolateral-prefrontal-cortex-are-altered-in-schizophrenia","title":{"rendered":"Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/twelve-hour-rhythms-in-transcript-expression-within-the-human-dorsolateral-prefrontal-cortex-are-altered-in-schizophrenia.jpg\"><\/a><\/p>\n<p>Twelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine organisms. While 12 h cycles are observed in human behavior and physiology, no study has measured 12 h rhythms in the human brain. Here, we identify 12 h rhythms in transcripts that either peak at sleep\/wake transitions (approximately 9 AM\/PM) or static times (approximately 3 PM\/AM) in the dorsolateral prefrontal cortex, a region involved in cognition. Subjects with schizophrenia (SZ) lose 12 h rhythms in genes associated with the unfolded protein response and neuronal structural maintenance. Moreover, genes involved in mitochondrial function and protein translation, which normally peak at sleep\/wake transitions, peak instead at static times in SZ, suggesting suboptimal timing of these essential processes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Twelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine organisms. While 12 h cycles are observed in human behavior and physiology, no study has measured 12 h rhythms in the human brain. Here, we identify 12 h rhythms in transcripts that either peak at sleep\/wake transitions (approximately 9 AM\/PM) or static times [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-156353","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/156353","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=156353"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/156353\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=156353"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=156353"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=156353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}