{"id":155831,"date":"2023-01-19T21:23:55","date_gmt":"2023-01-20T03:23:55","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/01\/new-nanoparticles-deliver-therapy-throughout-the-brain-and-edit-alzheimers-gene-in-mice"},"modified":"2023-01-19T21:23:55","modified_gmt":"2023-01-20T03:23:55","slug":"new-nanoparticles-deliver-therapy-throughout-the-brain-and-edit-alzheimers-gene-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/01\/new-nanoparticles-deliver-therapy-throughout-the-brain-and-edit-alzheimers-gene-in-mice","title":{"rendered":"New nanoparticles deliver therapy throughout the brain and edit Alzheimer\u2019s gene in mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-nanoparticles-deliver-therapy-throughout-the-brain-and-edit-alzheimers-gene-in-mice.jpg\"><\/a><\/p>\n<p>Gene therapies have the potential to treat neurological disorders like Alzheimer\u2019s and Parkinson\u2019s diseases, but they face a common barrier\u2014the blood-brain barrier. Now, researchers at the University of Wisconsin-Madison have developed a way to move therapies across the brain\u2019s protective membrane to deliver brain-wide therapy with a range of biological medications and treatments.<\/p>\n<p>\u201cThere is no cure yet for many devastating <a href=\"https:\/\/phys.org\/tags\/brain\/\" rel=\"tag\" class=\"\">brain<\/a> disorders,\u201d says Shaoqin \u201cSarah\u201d Gong, UW-Madison professor of ophthalmology and visual sciences and biomedical engineering and researcher at the Wisconsin Institute for Discovery. \u201cInnovative brain-targeted delivery strategies may change that by enabling noninvasive, safe and efficient delivery of CRISPR genome editors that could, in turn, lead to genome-editing therapies for these diseases.\u201d<\/p>\n<p>CRISPR is a molecular toolkit for editing <a href=\"https:\/\/phys.org\/tags\/genes\/\" rel=\"tag\" class=\"\">genes<\/a> (for example, to correct mutations that may cause disease), but the toolkit is only useful if it can get through security to the job site. The <a href=\"https:\/\/phys.org\/tags\/blood-brain+barrier\/\" rel=\"tag\" class=\"\">blood-brain barrier<\/a> is a membrane that selectively controls access to the brain, screening out toxins and pathogens that may be present in the bloodstream. Unfortunately, the <a href=\"https:\/\/phys.org\/tags\/barrier\/\" rel=\"tag\" class=\"\">barrier<\/a> bars some beneficial treatments, like certain vaccines and gene therapy packages, from reaching their targets because in lumps them in with hostile invaders.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gene therapies have the potential to treat neurological disorders like Alzheimer\u2019s and Parkinson\u2019s diseases, but they face a common barrier\u2014the blood-brain barrier. Now, researchers at the University of Wisconsin-Madison have developed a way to move therapies across the brain\u2019s protective membrane to deliver brain-wide therapy with a range of biological medications and treatments. \u201cThere is [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,38,412,4,47,1492],"tags":[],"class_list":["post-155831","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-engineering","category-genetics","category-nanotechnology","category-neuroscience","category-security"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/155831","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=155831"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/155831\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=155831"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=155831"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=155831"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}