{"id":155726,"date":"2023-01-18T04:26:59","date_gmt":"2023-01-18T10:26:59","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/01\/modified-crispr-based-enzymes-improve-the-prospect-of-inserting-entire-genes-into-the-genome"},"modified":"2023-01-18T04:26:59","modified_gmt":"2023-01-18T10:26:59","slug":"modified-crispr-based-enzymes-improve-the-prospect-of-inserting-entire-genes-into-the-genome","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/01\/modified-crispr-based-enzymes-improve-the-prospect-of-inserting-entire-genes-into-the-genome","title":{"rendered":"Modified CRISPR-based enzymes improve the prospect of inserting entire genes into the genome"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/modified-crispr-based-enzymes-improve-the-prospect-of-inserting-entire-genes-into-the-genome2.jpg\"><\/a><\/p>\n<p>Many genetic diseases are caused by diverse mutations spread across an entire gene, and designing genome editing approaches for each patient\u2019s mutation would be impractical and costly.<\/p>\n<p>Investigators at Massachusetts General Hospital (MGH) have recently developed an optimized method that improves the accuracy of inserting large DNA segments into a genome.<\/p>\n<p>This approach could be used to insert a whole normal or \u201cwild-type\u201d replacement gene, which could act as a blanket therapy for a disease irrespective of a patient\u2019s particular mutation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Many genetic diseases are caused by diverse mutations spread across an entire gene, and designing genome editing approaches for each patient\u2019s mutation would be impractical and costly. Investigators at Massachusetts General Hospital (MGH) have recently developed an optimized method that improves the accuracy of inserting large DNA segments into a genome. This approach could be [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-155726","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/155726","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=155726"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/155726\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=155726"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=155726"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=155726"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}