{"id":153877,"date":"2022-12-30T06:24:17","date_gmt":"2022-12-30T12:24:17","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/12\/alzheimers-mystery-solved-angry-immune-cells-in-brain-and-spinal-fluid-identified-as-culprit"},"modified":"2022-12-30T06:24:17","modified_gmt":"2022-12-30T12:24:17","slug":"alzheimers-mystery-solved-angry-immune-cells-in-brain-and-spinal-fluid-identified-as-culprit","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/12\/alzheimers-mystery-solved-angry-immune-cells-in-brain-and-spinal-fluid-identified-as-culprit","title":{"rendered":"Alzheimer\u2019s Mystery Solved: \u201cAngry\u201d Immune Cells in Brain and Spinal Fluid Identified As Culprit"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/alzheimers-mystery-solved-angry-immune-cells-in-brain-and-spinal-fluid-identified-as-culprit.jpg\"><\/a><\/p>\n<p>Gate\u2019s team of scientists observed genetic changes in the CSF immune cells in older healthy individuals that made the cells appear more activated and inflamed with advanced age.<\/p>\n<p>\u201cThe immune cells appear to be a little angry in older individuals,\u201d Gate said. \u201cWe think this anger might make these cells less functional, resulting in dysregulation of the brain\u2019s immune system.\u201d<\/p>\n<p>In the cognitively impaired group, inflamed T-cells cloned themselves and flowed into the CSF and brain as if they were following a radio signal, Gate said. Scientists found the cells had an overabundance of a cell receptor \u2014 CXCR6 \u2014 that acts as an antenna. This receptor receives a signal \u2014 CXCL16 \u2014 from the degenerating brain\u2019s microglia cells to enter the brain.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gate\u2019s team of scientists observed genetic changes in the CSF immune cells in older healthy individuals that made the cells appear more activated and inflamed with advanced age. \u201cThe immune cells appear to be a little angry in older individuals,\u201d Gate said. \u201cWe think this anger might make these cells less functional, resulting in dysregulation [\u2026]<\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,47],"tags":[],"class_list":["post-153877","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/153877","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=153877"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/153877\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=153877"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=153877"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=153877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}