{"id":153724,"date":"2022-12-27T15:23:44","date_gmt":"2022-12-27T21:23:44","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/12\/sepsis-is-one-of-the-most-expensive-medical-conditions-in-the-world-research-clarifies-how-it-can-lead-to-cell-death"},"modified":"2022-12-27T15:23:44","modified_gmt":"2022-12-27T21:23:44","slug":"sepsis-is-one-of-the-most-expensive-medical-conditions-in-the-world-research-clarifies-how-it-can-lead-to-cell-death","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/12\/sepsis-is-one-of-the-most-expensive-medical-conditions-in-the-world-research-clarifies-how-it-can-lead-to-cell-death","title":{"rendered":"Sepsis is one of the most expensive medical conditions in the world: Research clarifies how it can lead to cell death"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/NsPDjOX8QHA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p><a href=\"https:\/\/www.cdc.gov\/sepsis\/what-is-sepsis.html\">Sepsis<\/a> is a life-threatening condition arising from the body\u2019s overreactive response against an infection, leading it to injure its own tissues and organs. The first known reference to \u201csepsis\u201d dates back <a href=\"https:\/\/doi.org\/10.1007\/s00134-006-0392-2\">more than 2,700 years<\/a>, when the Greek poet Homer used it as a derivative of the word \u201csepo,\u201d meaning \u201cI rot.\u201d<\/p>\n<p>Despite dramatic improvements in understanding the immunological mechanisms behind <a href=\"https:\/\/medicalxpress.com\/tags\/sepsis\/\" rel=\"tag\" class=\"\">sepsis<\/a>, it still remains a major medical concern, affecting <a href=\"https:\/\/doi.org\/10.3949\/ccjm.87a.18143\">750,000 people in the U.S.<\/a> and <a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(19)32989-7\">nearly 50 million people globally<\/a> each year. Sepsis accounted for <a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(19)32989-7\">11 million deaths worldwide<\/a> in 2017, and is the <a href=\"https:\/\/doi.org\/10.1177\/2050312119835043\">most expensive medical condition<\/a> in the U.S., costing <a href=\"https:\/\/doi.org\/10.1097\/CCM.0000000000003342\">over tens of billions of dollars<\/a> annually.<\/p>\n<p><a href=\"https:\/\/medicine.tufts.edu\/people\/faculty\/alexander-poltorak\">We<\/a> <a href=\"https:\/\/scholar.google.com\/citations?user=VMa6rFgAAAAJ&hl=en\">are<\/a> <a href=\"https:\/\/medicine.tufts.edu\/people\/faculty\/hayley-muendlein\">researchers<\/a> who study how certain types of bacteria <a href=\"https:\/\/doi.org\/10.1126\/science.282.5396.2085\">interact with cells<\/a> during infections. We wanted to understand exactly how an overreactive <a href=\"https:\/\/medicalxpress.com\/tags\/immune+response\/\" rel=\"tag\" class=\"\">immune response<\/a> can result in detrimental and even lethal effects like sepsis. In our research, newly published in <i>Science Immunology<\/i>, we discovered the cells and molecules that potentially trigger death from sepsis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sepsis is a life-threatening condition arising from the body\u2019s overreactive response against an infection, leading it to injure its own tissues and organs. The first known reference to \u201csepsis\u201d dates back more than 2,700 years, when the Greek poet Homer used it as a derivative of the word \u201csepo,\u201d meaning \u201cI rot.\u201d Despite dramatic improvements [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-153724","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/153724","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=153724"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/153724\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=153724"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=153724"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=153724"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}