{"id":153438,"date":"2022-12-22T17:24:39","date_gmt":"2022-12-22T23:24:39","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/12\/de-novo-birth-of-functional-microproteins-in-the-human-lineage"},"modified":"2022-12-22T17:24:39","modified_gmt":"2022-12-22T23:24:39","slug":"de-novo-birth-of-functional-microproteins-in-the-human-lineage","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/12\/de-novo-birth-of-functional-microproteins-in-the-human-lineage","title":{"rendered":"De novo birth of functional microproteins in the human lineage"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/de-novo-birth-of-functional-microproteins-in-the-human-lineage.jpg\"><\/a><\/p>\n<p>Human microproteins encoded by small ORFs have been found to be functional. By comparing the corresponding sequences across vertebrate genomes, Vakirlis et al. show that a number of these originated \u201cfrom scratch\u201d from noncoding sequences, including two very recent cases unique to humans. These cases demonstrate the rapid evolution of genetic novelty.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Human microproteins encoded by small ORFs have been found to be functional. By comparing the corresponding sequences across vertebrate genomes, Vakirlis et al. show that a number of these originated \u201cfrom scratch\u201d from noncoding sequences, including two very recent cases unique to humans. These cases demonstrate the rapid evolution of genetic novelty.<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,385,412],"tags":[],"class_list":["post-153438","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-evolution","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/153438","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=153438"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/153438\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=153438"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=153438"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=153438"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}