{"id":153402,"date":"2022-12-22T09:22:19","date_gmt":"2022-12-22T15:22:19","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/12\/big-dynorphin-may-protect-neurons-from-the-accumulation-of-alzheimers-associated-amyloid"},"modified":"2022-12-22T09:22:19","modified_gmt":"2022-12-22T15:22:19","slug":"big-dynorphin-may-protect-neurons-from-the-accumulation-of-alzheimers-associated-amyloid","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/12\/big-dynorphin-may-protect-neurons-from-the-accumulation-of-alzheimers-associated-amyloid","title":{"rendered":"Big dynorphin may protect neurons from the accumulation of Alzheimer\u2019s-associated amyloid"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/big-dynorphin-may-protect-neurons-from-the-accumulation-of-alzheimers-associated-amyloid3.jpg\"><\/a><\/p>\n<p>\ud835\udc00\ud835\udc25\ud835\udc33\ud835\udc21\ud835\udc1e\ud835\udc22\ud835\udc26\ud835\udc1e\ud835\udc2b\u2019\ud835\udc2c \ud835\udc03\ud835\udc22\ud835\udc2c\ud835\udc1e\ud835\udc1a\ud835\udc2c\ud835\udc1e<\/p>\n<hr>\n<p>One of the main features of Alzheimer\u2019s disease is that the \u03b2-amyloid peptide, a molecule found inside neurons that has many diverse functions, begins to fold incorrectly and accumulates. This process, which ends up causing neuronal death, is linked to a series of other cellular alterations, making it difficult to determine whether they are the cause or the consequence. An example is the case of the deregulation of a type of dynorphin.<\/p>\n<p>Dynorphins are the body\u2019s own opioid peptides, which play a key role in many brain pathways. They are located in different areas of the brain, such as the hippocampus, amygdala or hypothalamus, and are involved in memory processes, emotion control, stress and pain, and among other processes. In addition, several studies have shown their involvement in epilepsy, stroke, addictions, depression and schizophrenia.<\/p>\n<p>Now, in a study published in the <i>Computational and Structural Biotechnology Journal<\/i>, a research group led by \u00c0lex Per\u00e1lvarez-Mar\u00edn, researcher in the Department of Biochemistry and Molecular Biology and the UAB Institut de Neuroci\u00e8ncies, has studied from computer models and <a href=\"https:\/\/medicalxpress.com\/tags\/cell+cultures\/\" rel=\"tag\" class=\"\">cell cultures<\/a> which interactions may exist between \u03b2-amyloid peptide and big dynorphin, to determine its role in \u03b2-amyloid accumulation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\ud835\udc00\ud835\udc25\ud835\udc33\ud835\udc21\ud835\udc1e\ud835\udc22\ud835\udc26\ud835\udc1e\ud835\udc2b\u2019\ud835\udc2c \ud835\udc03\ud835\udc22\ud835\udc2c\ud835\udc1e\ud835\udc1a\ud835\udc2c\ud835\udc1e One of the main features of Alzheimer\u2019s disease is that the \u03b2-amyloid peptide, a molecule found inside neurons that has many diverse functions, begins to fold incorrectly and accumulates. This process, which ends up causing neuronal death, is linked to a series of other cellular alterations, making it difficult to determine whether they [\u2026]<\/p>\n","protected":false},"author":461,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1523,47],"tags":[],"class_list":["post-153402","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-computing","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/153402","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/461"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=153402"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/153402\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=153402"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=153402"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=153402"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}