{"id":153303,"date":"2022-12-20T11:23:48","date_gmt":"2022-12-20T17:23:48","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/12\/investigators-discover-new-mechanism-to-boost-rna-therapies"},"modified":"2022-12-20T11:23:48","modified_gmt":"2022-12-20T17:23:48","slug":"investigators-discover-new-mechanism-to-boost-rna-therapies","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/12\/investigators-discover-new-mechanism-to-boost-rna-therapies","title":{"rendered":"Investigators discover new mechanism to boost RNA therapies"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/investigators-discover-new-mechanism-to-boost-rna-therapies3.jpg\"><\/a><\/p>\n<p>Investigators from the Smidt Heart Institute at Cedars-Sinai have identified how biological pacemaker cells\u2014cells that control your heartbeat\u2014can \u201cfight back\u201d against therapies to biologically correct abnormal heartbeat rates. The research also uncovered a new way to boost the effectiveness of RNA therapies by controlling this \u201cfighting back\u201d activity.<\/p>\n<p>This novel concept, published today in the peer-reviewed journal <i>Cell Reports Medicine<\/i>, is an important step in the evolution and creation of biological pacemakers\u2014which aim to one day replace traditional, electronic pacemakers.<\/p>\n<p>\u201cWe are all born with a specialized group of heart <a href=\"https:\/\/medicalxpress.com\/tags\/cells\/\" rel=\"tag\" class=\"\">cells<\/a> that set the pace for our heartbeats,\u201d said Eugenio Cingolani, MD, senior author of the study and director of the Cardiogenetics Program in the Smidt Heart Institute at Cedars-Sinai. \u201cBut in some people, this natural <a href=\"https:\/\/medicalxpress.com\/tags\/heartbeat\/\" rel=\"tag\" class=\"\">heartbeat<\/a> is too slow, leading to the need for an electronic pacemaker.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigators from the Smidt Heart Institute at Cedars-Sinai have identified how biological pacemaker cells\u2014cells that control your heartbeat\u2014can \u201cfight back\u201d against therapies to biologically correct abnormal heartbeat rates. The research also uncovered a new way to boost the effectiveness of RNA therapies by controlling this \u201cfighting back\u201d activity. This novel concept, published today in the [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,385,412],"tags":[],"class_list":["post-153303","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-evolution","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/153303","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=153303"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/153303\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=153303"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=153303"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=153303"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}