{"id":152710,"date":"2022-12-13T01:28:17","date_gmt":"2022-12-13T07:28:17","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/12\/unmasking-bace1-in-aging-and-age-related-diseases"},"modified":"2022-12-13T01:28:17","modified_gmt":"2022-12-13T07:28:17","slug":"unmasking-bace1-in-aging-and-age-related-diseases","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/12\/unmasking-bace1-in-aging-and-age-related-diseases","title":{"rendered":"Unmasking BACE1 in aging and age-related diseases"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/unmasking-bace1-in-aging-and-age-related-diseases2.jpg\"><\/a><\/p>\n<p>The BACE1 enzyme has a rate-limiting role in the amyloidogenic pathway (see Glossary) and has been extensively studied for its neuronal functions[1]. Since 2000, intensive efforts have focused on developing small-molecule BACE1 inhibitors to reduce amyloid \u03b2 (A\u03b2) production in Alzheimer\u2019s disease (AD) brains. However, human clinical trials involving most BACE1 inhibitors were stopped at Phase 2\/3 due to limited therapeutic benefits[2]. BACE1 inhibitors act by reducing A\u03b2-related pathologies in AD brains, that is, they are used to treat the symptoms rather than the underlying disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The BACE1 enzyme has a rate-limiting role in the amyloidogenic pathway (see Glossary) and has been extensively studied for its neuronal functions[1]. Since 2000, intensive efforts have focused on developing small-molecule BACE1 inhibitors to reduce amyloid \u03b2 (A\u03b2) production in Alzheimer\u2019s disease (AD) brains. However, human clinical trials involving most BACE1 inhibitors were stopped at [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,47],"tags":[],"class_list":["post-152710","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/152710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=152710"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/152710\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=152710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=152710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=152710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}