{"id":152696,"date":"2022-12-12T21:22:20","date_gmt":"2022-12-13T03:22:20","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/12\/genetically-modified-mice-pave-the-way-for-customized-medicine-in-a-rare-disease"},"modified":"2022-12-12T21:22:20","modified_gmt":"2022-12-13T03:22:20","slug":"genetically-modified-mice-pave-the-way-for-customized-medicine-in-a-rare-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/12\/genetically-modified-mice-pave-the-way-for-customized-medicine-in-a-rare-disease","title":{"rendered":"Genetically modified mice pave the way for customized medicine in a rare disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/genetically-modified-mice-pave-the-way-for-customized-medicine-in-a-rare-disease2.jpg\"><\/a><\/p>\n<p>An international research team led by Dr. Ana Guada\u00f1o at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior of the cell.<\/p>\n<p>Patients with mutations in this protein suffer from Allan-Herndon-Dudley syndrome, a <a href=\"https:\/\/medicalxpress.com\/tags\/rare+disease\/\" rel=\"tag\" class=\"\">rare disease<\/a> that takes the form of serious neurological alterations, in which each patient may reveal a different mutation of MCT8.<\/p>\n<p>This study, published in <i>Neurobiology of Disease<\/i>, describes the first avatar model for the disease\u2014in other words, the first animal model with the same <a href=\"https:\/\/medicalxpress.com\/tags\/genetic+alteration\/\" rel=\"tag\" class=\"\">genetic alteration<\/a> as various <a href=\"https:\/\/medicalxpress.com\/tags\/patients\/\" rel=\"tag\" class=\"\">patients<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An international research team led by Dr. Ana Guada\u00f1o at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior of the cell. [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412],"tags":[],"class_list":["post-152696","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/152696","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=152696"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/152696\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=152696"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=152696"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=152696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}