{"id":152659,"date":"2022-12-12T15:22:19","date_gmt":"2022-12-12T21:22:19","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/12\/car-t-cell-shows-promise-in-patients-with-lymphoma-of-the-brain-and-spinal-cord-in-early-trial"},"modified":"2022-12-12T15:22:19","modified_gmt":"2022-12-12T21:22:19","slug":"car-t-cell-shows-promise-in-patients-with-lymphoma-of-the-brain-and-spinal-cord-in-early-trial","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/12\/car-t-cell-shows-promise-in-patients-with-lymphoma-of-the-brain-and-spinal-cord-in-early-trial","title":{"rendered":"CAR-T-cell shows promise in patients with lymphoma of the brain and spinal cord in early trial"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/car-t-cell-shows-promise-in-patients-with-lymphoma-of-the-brain-and-spinal-cord-in-early-trial.jpg\"><\/a><\/p>\n<p>\ud835\udc02\ud835\udc00\ud835\udc11-\ud835\udc13-\ud835\udc1c\ud835\udc1e\ud835\udc25\ud835\udc25 \ud835\udc2c\ud835\udc21\ud835\udc28\ud835\udc30\ud835\udc2c \ud835\udc29\ud835\udc2b\ud835\udc28\ud835\udc26\ud835\udc22\ud835\udc2c\ud835\udc1e \ud835\udc22\ud835\udc27 \ud835\udc29\ud835\udc1a\ud835\udc2d\ud835\udc22\ud835\udc1e\ud835\udc27\ud835\udc2d\ud835\udc2c \ud835\udc30\ud835\udc22\ud835\udc2d\ud835\udc21 \ud835\udc25\ud835\udc32\ud835\udc26\ud835\udc29\ud835\udc21\ud835\udc28\ud835\udc26\ud835\udc1a \ud835\udc28\ud835\udc1f \ud835\udc2d\ud835\udc21\ud835\udc1e \ud835\udc1b\ud835\udc2b\ud835\udc1a\ud835\udc22\ud835\udc27 \ud835\udc1a\ud835\udc27\ud835\udc1d \ud835\udc2c\ud835\udc29\ud835\udc22\ud835\udc27\ud835\udc1a\ud835\udc25 \ud835\udc1c\ud835\udc28\ud835\udc2b\ud835\udc1d \ud835\udc22\ud835\udc27 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\ud835\ude4e\ud835\ude64\ud835\ude58\ud835\ude5e\ud835\ude5a\ud835\ude69\ud835\ude6e \ud835\ude64\ud835\ude5b \ud835\ude43\ud835\ude5a\ud835\ude62\ud835\ude56\ud835\ude69\ud835\ude64\ud835\ude61\ud835\ude64\ud835\ude5c\ud835\ude6e (\ud835\ude3c\ud835\ude4e\ud835\ude43) \ud835\ude3c\ud835\ude63\ud835\ude63\ud835\ude6a\ud835\ude56\ud835\ude61 \ud835\ude48\ud835\ude5a\ud835\ude5a\ud835\ude69\ud835\ude5e\ud835\ude63\ud835\ude5c.<\/p>\n<hr>\n<p>A CAR-T-cell therapy known as axicabtagene ciloleucel (axi-cel) is safe and shows encouraging signs of efficacy in a small pilot trial involving patients with lymphoma of the brain and\/or spinal cord, Dana-Farber Cancer Institute investigators report at the 64th American Society of Hematology (ASH) Annual Meeting.<\/p>\n<p>The research features an in-depth, molecular study of individual CAR-T cells isolated from patients\u2019 blood and cerebrospinal fluid (CSF), which surrounds the brain and spinal cord. This unprecedented analysis, conducted in collaboration with the Cellular Therapeutics and Systems Immunology Lab (CTSI), directed by Leslie Kean, MD, PhD, at Dana-Farber and Boston Children\u2019s Hospital, reveals a surprising difference between the two CAR-T-cell populations: the cells in the CSF display a molecular signature that indicates activation of the interferon pathway, an important step in rallying the immune system. These studies are reported in two oral abstracts at ASH. \u201cFor many patients with lymphoma of the central nervous system, there aren\u2019t great treatment options,\u201d said Dana-Farber\u2019s <a href=\"https:\/\/www.dana-farber.org\/find-a-doctor\/caron-a-jacobson\/\">Caron Jacobson, MD, MMSc<\/a>, who led the trial and will present the findings at ASH. \u201cOur early results suggest that expanding the applicability of CAR-T cells to this indication could improve patient outcomes.\u201d<\/p>\n<p>Lymphomas can begin within the brain or spinal cord, or the tumors can spread to those sites (known collectively as the central nervous system or CNS) after they originate in other parts of the body. While the underlying biology of these primary and secondary CNS lymphomas can be quite different, these cancers are often difficult to treat, especially once the tumors evade standard treatments. In that case, patients typically do not live more than 2 years.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\ud835\udc02\ud835\udc00\ud835\udc11-\ud835\udc13-\ud835\udc1c\ud835\udc1e\ud835\udc25\ud835\udc25 \ud835\udc2c\ud835\udc21\ud835\udc28\ud835\udc30\ud835\udc2c \ud835\udc29\ud835\udc2b\ud835\udc28\ud835\udc26\ud835\udc22\ud835\udc2c\ud835\udc1e \ud835\udc22\ud835\udc27 \ud835\udc29\ud835\udc1a\ud835\udc2d\ud835\udc22\ud835\udc1e\ud835\udc27\ud835\udc2d\ud835\udc2c \ud835\udc30\ud835\udc22\ud835\udc2d\ud835\udc21 \ud835\udc25\ud835\udc32\ud835\udc26\ud835\udc29\ud835\udc21\ud835\udc28\ud835\udc26\ud835\udc1a \ud835\udc28\ud835\udc1f \ud835\udc2d\ud835\udc21\ud835\udc1e \ud835\udc1b\ud835\udc2b\ud835\udc1a\ud835\udc22\ud835\udc27 \ud835\udc1a\ud835\udc27\ud835\udc1d \ud835\udc2c\ud835\udc29\ud835\udc22\ud835\udc27\ud835\udc1a\ud835\udc25 \ud835\udc1c\ud835\udc28\ud835\udc2b\ud835\udc1d \ud835\udc22\ud835\udc27 \ud835\udc1e\ud835\udc1a\ud835\udc2b\ud835\udc25\ud835\udc32 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