{"id":152139,"date":"2022-12-07T23:43:49","date_gmt":"2022-12-08T05:43:49","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/12\/do-mitochondria-hold-the-key-to-a-parkinsons-breakthrough"},"modified":"2022-12-07T23:43:49","modified_gmt":"2022-12-08T05:43:49","slug":"do-mitochondria-hold-the-key-to-a-parkinsons-breakthrough","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/12\/do-mitochondria-hold-the-key-to-a-parkinsons-breakthrough","title":{"rendered":"Do mitochondria hold the key to a Parkinson\u2019s breakthrough?"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/do-mitochondria-hold-the-key-to-a-parkinsons-breakthrough2.jpg\"><\/a><\/p>\n<p>Biotech startup <a href=\"https:\/\/www.lucytherapeutics.com\" target=\"_blank\" rel=\"noreferrer noopener\">Lucy Therapeutics<\/a> is developing mitochondrial-based small molecule therapies for neurological diseases and recently revealed the first two drugs to emerge from its lead programme targeting Parkinson\u2019s. The company, which takes its name from the <a href=\"https:\/\/iho.asu.edu\/about\/lucys-story\" target=\"_blank\" rel=\"noreferrer noopener\">3.2-million-year-old fossil<\/a> of an ancestor of humankind, presented \u201cpromising preclinical data\u201d at the Michael J Fox Foundation\u2019s <a href=\"https:\/\/www.michaeljfox.org\/2022-pd-therapeutics-conference\" target=\"_blank\" rel=\"noreferrer noopener\">Parkinson\u2019s Disease Therapeutics Conference<\/a> in October.<\/p>\n<p>The data shown by Lucy Therapeutics demonstrated that its compounds were able to reverse mitochondrial dysfunctions linked to Parkinson\u2019s. In cellular models of the disease, the drugs boosted levels of cellular energy molecule ATP, prevented the death of neurons, and reduced levels of other hallmarks of Parkinson\u2019s, including a-synuclein.<\/p>\n<p><strong><em>Longevity. Technology: <a href=\"https:\/\/longevity.technology\/tag\/mitochondria\/\" target=\"_blank\" rel=\"noreferrer noopener\">Mitochondria<\/a> are widely known as the \u2018power generators\u2019 within our cells, and their dysfunction has been linked to a range of age-related diseases. But the role of mitochondria extends beyond cellular energy as they also dictate many of a cell\u2019s key functions. Lucy Therapeutics was founded on the hypothesis that diseases with rate-limiting steps involving mitochondrial dysfunction can potentially be treated by modulating key mitochondrial protein targets. To find out more, we caught up with the company\u2019s founder and CEO, Dr Amy Ripka.<\/em><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Biotech startup Lucy Therapeutics is developing mitochondrial-based small molecule therapies for neurological diseases and recently revealed the first two drugs to emerge from its lead programme targeting Parkinson\u2019s. The company, which takes its name from the 3.2-million-year-old fossil of an ancestor of humankind, presented \u201cpromising preclinical data\u201d at the Michael J Fox Foundation\u2019s Parkinson\u2019s Disease [\u2026]<\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,47],"tags":[],"class_list":["post-152139","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/152139","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=152139"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/152139\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=152139"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=152139"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=152139"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}