{"id":151870,"date":"2022-12-04T21:30:30","date_gmt":"2022-12-05T03:30:30","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/12\/swelling-along-brains-axons-may-be-true-culprit-in-alzheimers-disease"},"modified":"2022-12-04T21:30:30","modified_gmt":"2022-12-05T03:30:30","slug":"swelling-along-brains-axons-may-be-true-culprit-in-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/12\/swelling-along-brains-axons-may-be-true-culprit-in-alzheimers-disease","title":{"rendered":"Swelling along brain\u2019s axons may be true culprit in Alzheimer\u2019s disease"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/WLxbTIQ8cqo?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>The formation of amyloid plaques in the brain is a hallmark of Alzheimer\u2019s disease. But drugs designed to reduce accumulations of these plaques have so far yielded, at best, mixed results in clinical trials.<\/p>\n<p>Yale researchers have found, however, that swelling caused by a byproduct of these plaques may be the true cause of the disease\u2019s debilitating symptoms, they report Nov. 30 in the journal <a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05491-6\">Nature<\/a>. And they identified a biomarker that may help physicians better diagnose Alzheimer\u2019s and provide a target for future therapies.<\/p>\n<p>According to their findings, each formation of plaque can cause an accumulation of spheroid-shaped swellings along hundreds of axons \u2014 the thin cellular wires that connect the brain\u2019s neurons \u2014 near amyloid plaque deposits. The swellings are caused by the gradual accumulation of organelles within cells known as lysosomes, which are known to digest cellular waste, researchers found. As the swellings enlarge, researchers say, they can blunt the transmission of normal electrical signals from one region of the brain to another.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The formation of amyloid plaques in the brain is a hallmark of Alzheimer\u2019s disease. But drugs designed to reduce accumulations of these plaques have so far yielded, at best, mixed results in clinical trials. Yale researchers have found, however, that swelling caused by a byproduct of these plaques may be the true cause of the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-151870","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/151870","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=151870"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/151870\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=151870"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=151870"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=151870"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}