{"id":151042,"date":"2022-11-24T22:25:17","date_gmt":"2022-11-25T04:25:17","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/11\/new-crispr-based-tool-inserts-large-dna-sequences-at-desired-sites-in-cells"},"modified":"2022-11-24T22:25:17","modified_gmt":"2022-11-25T04:25:17","slug":"new-crispr-based-tool-inserts-large-dna-sequences-at-desired-sites-in-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/11\/new-crispr-based-tool-inserts-large-dna-sequences-at-desired-sites-in-cells","title":{"rendered":"New CRISPR-based tool inserts large DNA sequences at desired sites in cells"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-crispr-based-tool-inserts-large-dna-sequences-at-desired-sites-in-cells2.jpg\"><\/a><\/p>\n<p>Building on the CRISPR gene-editing system, MIT researchers have designed a new tool that can snip out faulty genes and replace them with new ones, in a safer and more efficient way.<\/p>\n<p>Using this system, the researchers showed that they could deliver <a href=\"https:\/\/phys.org\/tags\/genes\/\" rel=\"tag\" class=\"\">genes<\/a> as long as 36,000 DNA base pairs to several types of human cells, as well as to liver cells in mice. The new technique, known as PASTE, could hold promise for treating diseases that are caused by <a href=\"https:\/\/phys.org\/tags\/defective+genes\/\" rel=\"tag\" class=\"\">defective genes<\/a> with a large number of mutations, such as cystic fibrosis.<\/p>\n<p>\u201cIt\u2019s a new genetic way of potentially targeting these really hard to treat diseases,\u201d says Omar Abudayyeh, a McGovern Fellow at MIT\u2019s McGovern Institute for Brain Research. \u201cWe wanted to work toward what <a href=\"https:\/\/phys.org\/tags\/gene+therapy\/\" rel=\"tag\" class=\"\">gene therapy<\/a> was supposed to do at its original inception, which is to replace genes, not just correct individual mutations.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Building on the CRISPR gene-editing system, MIT researchers have designed a new tool that can snip out faulty genes and replace them with new ones, in a safer and more efficient way. Using this system, the researchers showed that they could deliver genes as long as 36,000 DNA base pairs to several types of human [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-151042","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/151042","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=151042"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/151042\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=151042"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=151042"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=151042"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}