{"id":150812,"date":"2022-11-22T16:24:51","date_gmt":"2022-11-22T22:24:51","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/11\/primordial-super-enhancers-provide-early-snapshot-of-the-mechanisms-that-allowed-for-multicellularity"},"modified":"2022-11-22T16:24:51","modified_gmt":"2022-11-22T22:24:51","slug":"primordial-super-enhancers-provide-early-snapshot-of-the-mechanisms-that-allowed-for-multicellularity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/11\/primordial-super-enhancers-provide-early-snapshot-of-the-mechanisms-that-allowed-for-multicellularity","title":{"rendered":"\u2018Primordial super-enhancers\u2019 provide early snapshot of the mechanisms that allowed for multicellularity"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/primordial-super-enhancers-provide-early-snapshot-of-the-mechanisms-that-allowed-for-multicellularity.jpg\"><\/a><\/p>\n<p>New research at the University of Chicago has found that the same machinery used by mammalian cells to drive cellular differentiation also plays a critical role in activating genes in yeast in response to environmental stress.<\/p>\n<p>The results, which were published in <i>Molecular Cell<\/i>, suggest that these machines, known as transcriptional condensates, are an ancient, conserved tool used by <a href=\"https:\/\/phys.org\/tags\/eukaryotic+cells\/\" rel=\"tag\" class=\"\">eukaryotic cells<\/a> to promote high level <a href=\"https:\/\/phys.org\/tags\/gene+expression\/\" rel=\"tag\" class=\"\">gene expression<\/a> for over a billion years. The findings are helping to not only better explain how cells respond dynamically to environmental cues but also have implications for understanding human diseases such as cancer and neurodegeneration.<\/p>\n<p>The study extends existing research on transcriptional condensates in <a href=\"https:\/\/phys.org\/tags\/mammalian+cells\/\" rel=\"tag\" class=\"\">mammalian cells<\/a> into yeast and their heat shock response\u2014how cells respond to high temperatures. \u201cThe heat shock response is ancient,\u201d said David Pincus, Ph.D., Assistant Professor of Molecular Genetics and Cell Biology at UChicago. \u201cThis response existed long before there were people\u2014long before there were even yeast. It predates the split between prokaryotes and eukaryotes, so it\u2019s a really fundamental and important cellular response.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New research at the University of Chicago has found that the same machinery used by mammalian cells to drive cellular differentiation also plays a critical role in activating genes in yeast in response to environmental stress. The results, which were published in Molecular Cell, suggest that these machines, known as transcriptional condensates, are an ancient, [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-150812","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/150812","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=150812"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/150812\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=150812"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=150812"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=150812"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}