{"id":149784,"date":"2022-11-09T15:25:36","date_gmt":"2022-11-09T21:25:36","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/11\/scientists-unveil-the-functional-landscape-of-essential-genes"},"modified":"2022-11-09T15:25:36","modified_gmt":"2022-11-09T21:25:36","slug":"scientists-unveil-the-functional-landscape-of-essential-genes","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/11\/scientists-unveil-the-functional-landscape-of-essential-genes","title":{"rendered":"Scientists unveil the functional landscape of essential genes"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scientists-unveil-the-functional-landscape-of-essential-genes.jpg\"><\/a><\/p>\n<p>A team of scientists at Whitehead Institute and the Broad Institute of MIT and Harvard have systematically evaluated the functions of more than 5,000 essential human genes using a novel, pooled, imaged-based screening method. Their analysis harnesses CRISPR\/Cas9 to knock out gene activity and forms a first-of-its-kind resource for understanding and visualizing gene function in a wide range of cellular processes with both spatial and temporal resolution.<\/p>\n<p>The team\u2019s findings, published in the journal <i>Cell<\/i>, span over 31 million <a href=\"https:\/\/phys.org\/tags\/individual+cells\/\" rel=\"tag\" class=\"\">individual cells<\/a> and include <a href=\"https:\/\/phys.org\/tags\/quantitative+data\/\" rel=\"tag\" class=\"\">quantitative data<\/a> on hundreds of different parameters that enable predictions about how genes work and operate together.<\/p>\n<p>\u201cFor my entire career, I\u2019ve wanted to see what happens in cells when the function of an essential gene is eliminated,\u201d said Iain Cheeseman, a senior author of the study and a member of Whitehead Institute. \u201cNow, we can do that, not just for one gene but for every <a href=\"https:\/\/phys.org\/tags\/single+gene\/\" rel=\"tag\" class=\"\">single gene<\/a> that matters for a human cell dividing in a dish, and it\u2019s enormously powerful. The resource we\u2019ve created will benefit not just our own lab but labs around the world.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team of scientists at Whitehead Institute and the Broad Institute of MIT and Harvard have systematically evaluated the functions of more than 5,000 essential human genes using a novel, pooled, imaged-based screening method. Their analysis harnesses CRISPR\/Cas9 to knock out gene activity and forms a first-of-its-kind resource for understanding and visualizing gene function in [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-149784","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/149784","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=149784"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/149784\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=149784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=149784"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=149784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}