{"id":149740,"date":"2022-11-08T19:24:09","date_gmt":"2022-11-09T01:24:09","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/11\/reprogrammed-crispr-cas13b-suppresses-sars-cov-2-replication-and-circumvents-its-mutational-escape-through-mismatch-tolerance-communications"},"modified":"2022-11-08T19:24:09","modified_gmt":"2022-11-09T01:24:09","slug":"reprogrammed-crispr-cas13b-suppresses-sars-cov-2-replication-and-circumvents-its-mutational-escape-through-mismatch-tolerance-communications","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/11\/reprogrammed-crispr-cas13b-suppresses-sars-cov-2-replication-and-circumvents-its-mutational-escape-through-mismatch-tolerance-communications","title":{"rendered":"Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance Communications"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/reprogrammed-crispr-cas13b-suppresses-sars-cov-2-replication-and-circumvents-its-mutational-escape-through-mismatch-tolerance-communications.jpg\"><\/a><\/p>\n<p>Cas13b can be harnessed to target and degrade RNA transcripts inside a cellular environment. Here the authors reprogram Cas13b to target SARSCoV-2 transcripts in infected mammalian cells and reveal its resilience to variants thanks to single mismatch tolerance.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cas13b can be harnessed to target and degrade RNA transcripts inside a cellular environment. Here the authors reprogram Cas13b to target SARSCoV-2 transcripts in infected mammalian cells and reveal its resilience to variants thanks to single mismatch tolerance.<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-149740","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/149740","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=149740"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/149740\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=149740"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=149740"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=149740"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}