{"id":149320,"date":"2022-11-02T07:22:52","date_gmt":"2022-11-02T12:22:52","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/11\/sites-in-the-brain-where-rna-is-edited-could-help-our-understanding-of-neurodevelopment-and-disease"},"modified":"2022-11-02T07:22:52","modified_gmt":"2022-11-02T12:22:52","slug":"sites-in-the-brain-where-rna-is-edited-could-help-our-understanding-of-neurodevelopment-and-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/11\/sites-in-the-brain-where-rna-is-edited-could-help-our-understanding-of-neurodevelopment-and-disease","title":{"rendered":"Sites in the brain where RNA is edited could help our understanding of neurodevelopment and disease"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/sites-in-the-brain-where-rna-is-edited-could-help-our-understanding-of-neurodevelopment-and-disease.jpg\"><\/a><\/p>\n<p>Mount Sinai researchers have cataloged thousands of sites in the brain where RNA is modified throughout the human lifespan in a process known as adenosine-to-inosine (A-to-I) editing, offering important new avenues for understanding the cellular and molecular mechanisms of brain development and how they factor into both health and disease.<\/p>\n<p>In a study published in <i>Cell Reports<\/i>, the team described how the rate of RNA editing in the brain increases as individuals age, with implications for dissecting the pathology of altered A-to-I editing across a range of neurodevelopmental and aging disorders.<\/p>\n<p>\u201cOur work provides more nuanced and accurate insights into the contribution of RNA modifications by A-to-I editing during human brain development,\u201d says senior author Michael Breen, Ph.D., Assistant Professor of Psychiatry, and Genetics and Genomic Sciences, at the Icahn School of Medicine at Mount Sinai, and a member of the Seaver Center for Autism Research and Treatment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mount Sinai researchers have cataloged thousands of sites in the brain where RNA is modified throughout the human lifespan in a process known as adenosine-to-inosine (A-to-I) editing, offering important new avenues for understanding the cellular and molecular mechanisms of brain development and how they factor into both health and disease. In a study published in [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269,47],"tags":[],"class_list":["post-149320","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/149320","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=149320"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/149320\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=149320"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=149320"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=149320"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}