{"id":148715,"date":"2022-10-23T04:25:11","date_gmt":"2022-10-23T09:25:11","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/10\/ut-austin-scientists-design-safer-cas9-with-improved-crispr-gene-editing-accuracy"},"modified":"2022-10-23T04:25:11","modified_gmt":"2022-10-23T09:25:11","slug":"ut-austin-scientists-design-safer-cas9-with-improved-crispr-gene-editing-accuracy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/10\/ut-austin-scientists-design-safer-cas9-with-improved-crispr-gene-editing-accuracy","title":{"rendered":"UT Austin scientists design safer Cas9 with improved CRISPR gene editing accuracy"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/ut-austin-scientists-design-safer-cas9-with-improved-crispr-gene-editing-accuracy2.jpg\"><\/a><\/p>\n<p>The CRISPR system, which involves a Cas enzyme to cut DNA, is a powerful tool for gene editing. But the genetic scissors sometimes make changes at the wrong place, creating a major safety problem that could limit their therapeutic use.<\/p>\n<p>Now, scientists at the University of Texas (UT) at Austin have refined the Cas9 protein used in the Nobel Prize-winning CRISPR-Cas9 tool. The new version, dubbed SuperFi-Cas9, was thousands of times less likely to perform off-target editing but just as efficient at on-target editing as the original version, the team said in a paper published in <a href=\"https:\/\/www.nature.com\/articles\/s41586-022-04470-1\" target=\"_blank\">Nature<\/a>.<\/p>\n<p>\u201cThis really could be a game-changer in terms of a wider application of the CRISPR-Cas systems in gene editing,\u201d Kenneth Johnson, Ph.D., the study\u2019s co-senior author, <a href=\"https:\/\/www.eurekalert.org\/news-releases\/944893?\" target=\"_blank\">said<\/a> in a statement.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The CRISPR system, which involves a Cas enzyme to cut DNA, is a powerful tool for gene editing. But the genetic scissors sometimes make changes at the wrong place, creating a major safety problem that could limit their therapeutic use. Now, scientists at the University of Texas (UT) at Austin have refined the Cas9 protein [\u2026]<\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412],"tags":[],"class_list":["post-148715","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/148715","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=148715"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/148715\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=148715"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=148715"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=148715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}