{"id":148552,"date":"2022-10-20T04:22:22","date_gmt":"2022-10-20T09:22:22","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/10\/the-physiological-effects-of-dandelion-taraxacum-officinale-in-type-2-diabetes"},"modified":"2022-10-20T04:22:22","modified_gmt":"2022-10-20T09:22:22","slug":"the-physiological-effects-of-dandelion-taraxacum-officinale-in-type-2-diabetes","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/10\/the-physiological-effects-of-dandelion-taraxacum-officinale-in-type-2-diabetes","title":{"rendered":"The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/the-physiological-effects-of-dandelion-taraxacum-officinale-in-type-2-diabetes2.jpg\"><\/a><\/p>\n<p>The tremendous rise in the economic burden of type 2 diabetes (T2D) has prompted a search for alternative and less expensive medicines. Dandelion offers a compelling profile of bioactive components with potential anti-diabetic properties. The <em>Taraxacum<\/em> genus from the Asteraceae family is found in the temperate zone of the Northern hemisphere. It is available in several areas around the world. In many countries, it is used as food and in some countries as therapeutics for the control and treatment of T2D. The anti-diabetic properties of dandelion are attributed to bioactive chemical components; these include chicoric acid, taraxasterol (TS), chlorogenic acid, and sesquiterpene lactones. Studies have outlined the useful pharmacological profile of dandelion for the treatment of an array of diseases, although little attention has been paid to the effects of its bioactive components on T2D to date. This review recapitulates previous work on dandelion and its potential for the treatment and prevention of T2D, highlighting its anti-diabetic properties, the structures of its chemical components, and their potential mechanisms of action in T2D. Although initial research appears promising, data on the cellular impact of dandelion are limited, necessitating further work on clonal \u03b2-cell lines (INS-1E), \u03b1-cell lines, and human skeletal cell lines for better identification of the active components that could be of use in the control and treatment of T2D. In fact, extensive <em>in-vitro<\/em>, <em>in-vivo<\/em>, and clinical research is required to investigate further the pharmacological, physiological, and biochemical mechanisms underlying the effects of dandelion-derived compounds on T2D.<\/p>\n<p><strong class=\"\">Keywords: <\/strong>type 2 diabetes, dandelion, chlorogenic acid, chicory acid, taraxasterol, sesquiterpene.<\/p>\n<p><strong>Abbreviations<\/strong>: ADP \u2014 adenosine diphosphate; AFLD \u2014 alcoholic fatty liver disease; AMPK \u2014 adenosine monophosphate-activated protein kinase; ATP \u2014 adenosine triphosphate; cAMP \u2014 cyclic adenosine monophosphate; CGA \u2014 chlorogenic acid; CoA \u2014 coenzyme A; CRA \u2014 chicory acid; DAG \u2014 diacylglycerol; DBD \u2014 DNA-binding domain; DNA \u2014 deoxyribonucleic acid; DPPH \u2014 2,2-diphenyl-1-picrylhydrazyl; Dw \u2014 dry weight; FOS \u2014 fructose oligosaccharide; G6P \u2014 glucose-6-phosphate; GDP \u2014 guanosine 5\u2019-diphosphate; GLP-1 \u2014 glucagon-like peptide 1; GLUT2 \u2014 glucose transporter 2; GLUT4 \u2014 muscle glucose transporter protein 4; GPCR \u2014 G protein-coupled receptor; GTP \u2014 guanosine triphosphate; HNB \u2014 2-hydroxy-5-nitrobenzenaledehyde; HPLC \u2014 high-pressure liquid chromatography; IC<sub>50<\/sub> \u2014 half maximal inhibitory concentration; IDF \u2014 International Diabetes Federation; IDX-1 \u2014 islet duodenum homeobox 1; IL-1\u03b1 \u2014 interleukin 1 alpha; INS-1E \u2014 rat insulinoma clonal beta-cell line; IR \u2014 insulin receptor; IRS-1 \u2014 insulin receptor substrate 1; Km \u2014 Michaelis constant; IP3 \u2014 inositol triphosphate; IRS-1 \u2014 insulin receptor substrate 1; LBD \u2014 ligand-binding domain; LC-DAD \u2014 liquid chromatography with (photo) diode array detection; LPS \u2014 lipopolysaccharide; MAPK \u2014 mitogen-activated protein kinase; NADH \u2014 nicotinamide adenine dinucleotide; NAFLD \u2014 non-alcoholic fatty liver disease; NF-\u03bab \u2014 nuclear factor kappa B; NO \u2014 nitric oxide; PI3K \u2014 phosphatidylinositol 3 kinase; PKA \u2014 protein kinase A; PKC \u2014 protein kinase C; PPAR-\u03b3 \u2014 peroxisome proliferator-activated receptor gamma; ROS \u2014 reactive oxygen species; RxR \u2014 retinoid X receptor; SEL \u2014 sesquiterpene lactones; SUR1 \u2014 sulphonylurea receptor 1; T2D \u2014 type 2 diabetes; TAG \u2014 triacylglycerol; TNF-\u03b1 \u2014 tumor necrosis factor; TO \u2014 Taraxacum officinale; TS \u2014 taraxasterol; UPLC-MS\/MS \u2014 ultra-performance liquid chromatography \u2014 tandem mass spectrometry; UV\/VIS \u2014 ultraviolet visible; WHO \u2014 World Health Organization.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The tremendous rise in the economic burden of type 2 diabetes (T2D) has prompted a search for alternative and less expensive medicines. Dandelion offers a compelling profile of bioactive components with potential anti-diabetic properties. The Taraxacum genus from the Asteraceae family is found in the temperate zone of the Northern hemisphere. It is available in [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,1523,39],"tags":[],"class_list":["post-148552","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-computing","category-economics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/148552","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=148552"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/148552\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=148552"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=148552"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=148552"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}