{"id":147102,"date":"2022-09-26T19:22:58","date_gmt":"2022-09-27T00:22:58","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/09\/new-study-allows-scientists-to-test-therapeutics-for-rare-neurodegenerative-disease-affecting-young-children"},"modified":"2022-09-26T19:22:58","modified_gmt":"2022-09-27T00:22:58","slug":"new-study-allows-scientists-to-test-therapeutics-for-rare-neurodegenerative-disease-affecting-young-children","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/09\/new-study-allows-scientists-to-test-therapeutics-for-rare-neurodegenerative-disease-affecting-young-children","title":{"rendered":"New study allows scientists to test therapeutics for rare neurodegenerative disease affecting young children"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-study-allows-scientists-to-test-therapeutics-for-rare-neurodegenerative-disease-affecting-young-children2.jpg\"><\/a><\/p>\n<p>For the first time, scientists will be able to test therapeutics for a group of rare neurodegenerative diseases that affect infants and young children, thanks to a new research model created by scientists at the University of Wisconsin-Madison. Their results are published in the Proceedings of the National Academy of Sciences.<\/p>\n<p>Hereditary spastic paraplegias (HSPs) are a group of <a href=\"https:\/\/phys.org\/tags\/neurodegenerative+diseases\/\" rel=\"tag\" class=\"\">neurodegenerative diseases<\/a> caused by <a href=\"https:\/\/phys.org\/tags\/genetic+mutations\/\" rel=\"tag\" class=\"\">genetic mutations<\/a>. They lead tens of thousands of children to develop increased muscle tone in their lower extremities, causing weakness in their legs and ultimately affecting their ability to crawl or walk.<\/p>\n<p>\u201cKids as early as six months of age that have these <a href=\"https:\/\/phys.org\/tags\/mutations\/\" rel=\"tag\" class=\"\">mutations<\/a> start to show signs of disease,\u201d says Anjon Audhya, a professor in the Department of Biomolecular Chemistry at UW-Madison. \u201cBetween two and five years of age, these kids become wheelchair-bound, and they unfortunately will never be able to walk.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>For the first time, scientists will be able to test therapeutics for a group of rare neurodegenerative diseases that affect infants and young children, thanks to a new research model created by scientists at the University of Wisconsin-Madison. Their results are published in the Proceedings of the National Academy of Sciences. Hereditary spastic paraplegias (HSPs) [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,47],"tags":[],"class_list":["post-147102","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/147102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=147102"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/147102\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=147102"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=147102"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=147102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}