{"id":146963,"date":"2022-09-24T15:22:18","date_gmt":"2022-09-24T20:22:18","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/09\/salk-scientists-modify-crispr-to-epigenetically-treat-diabetes-kidney-disease-muscular-dystrophy"},"modified":"2022-09-24T15:22:18","modified_gmt":"2022-09-24T20:22:18","slug":"salk-scientists-modify-crispr-to-epigenetically-treat-diabetes-kidney-disease-muscular-dystrophy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/09\/salk-scientists-modify-crispr-to-epigenetically-treat-diabetes-kidney-disease-muscular-dystrophy","title":{"rendered":"Salk scientists modify CRISPR to epigenetically treat diabetes, kidney disease, muscular dystrophy"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/zhS0CZprpaA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Circa 2017 <span class=\"wp-smiley emoji emoji-face_with_colon_three\" title=\":3\">face_with_colon_three<\/span> <\/p>\n<hr>\n<p>LA JOLLA\u2014Salk scientists have created a new version of the CRISPR\/Cas9 genome editing technology that allows them to activate genes without creating breaks in the DNA, potentially circumventing a major hurdle to using gene editing technologies to treat human diseases.<\/p>\n<p>Most CRISPR\/Cas9 systems work by creating \u201cdouble-strand breaks\u201d (DSBs) in regions of the genome targeted for editing or for deletion, but many researchers are opposed to creating such breaks in the DNA of living humans. As a proof of concept, the Salk group used their new approach to treat several diseases, including diabetes, acute kidney disease, and muscular dystrophy, in mouse models.<\/p>\n<p>\u201cAlthough many studies have demonstrated that CRISPR\/Cas9 can be applied as a powerful tool for gene therapy, there are growing concerns regarding unwanted mutations generated by the double-strand breaks through this technology,\u201d says <a href=\"https:\/\/www.salk.edu\/scientist\/juan-carlos-izpisua-belmonte\/\">Juan Carlos Izpisua Belmonte<\/a>, a professor in Salk\u2019s Gene Expression Laboratory and senior author of the new paper, published in <a href=\"http:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(17)31247-3\"><em>Cell<\/em><\/a> on December 7, 2017. \u201cWe were able to get around that concern.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Circa 2017 face_with_colon_three LA JOLLA\u2014Salk scientists have created a new version of the CRISPR\/Cas9 genome editing technology that allows them to activate genes without creating breaks in the DNA, potentially circumventing a major hurdle to using gene editing technologies to treat human diseases. Most CRISPR\/Cas9 systems work by creating \u201cdouble-strand breaks\u201d (DSBs) in regions of [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412],"tags":[],"class_list":["post-146963","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/146963","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=146963"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/146963\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=146963"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=146963"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=146963"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}