{"id":146847,"date":"2022-09-23T03:22:52","date_gmt":"2022-09-23T08:22:52","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/09\/scientists-use-crispr-to-condense-a-million-years-of-evolution-into-mere-months"},"modified":"2022-09-23T03:22:52","modified_gmt":"2022-09-23T08:22:52","slug":"scientists-use-crispr-to-condense-a-million-years-of-evolution-into-mere-months","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/09\/scientists-use-crispr-to-condense-a-million-years-of-evolution-into-mere-months","title":{"rendered":"Scientists Use CRISPR to Condense a Million Years of Evolution Into Mere Months"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scientists-use-crispr-to-condense-a-million-years-of-evolution-into-mere-months3.jpg\"><\/a><\/p>\n<p>Chromosome-level engineering is a completely different beast: it\u2019s like rearranging multiple paragraphs or shifting complete sections of an article and simultaneously hoping the changes add capabilities that can be passed onto the next generation.<\/p>\n<p>Reprogramming life isn\u2019t easy. Xiao Zhu\u2019s DNA makeup is built from genetic letters already optimized by eons of evolutionary pressure. It\u2019s no surprise that tinkering with an established genomic book often results in life that\u2019s not viable. So far, only yeast have survived the rejiggering of their chromosomes.<\/p>\n<p>The <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abm1964\">new study<\/a>, published in <i>Science<\/i>, made the technology possible for mice. The team artificially fused together chunks from mice chromosomes. One fused pair made from chromosomes four and five was able to support embryos that developed into healthy\u2014if somewhat strangely behaved\u2014mice. Remarkably, even with this tectonic shift to their normal genetics, the mice could reproduce and pass on their engineered genetic quirks to a second generation of offspring.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chromosome-level engineering is a completely different beast: it\u2019s like rearranging multiple paragraphs or shifting complete sections of an article and simultaneously hoping the changes add capabilities that can be passed onto the next generation. Reprogramming life isn\u2019t easy. Xiao Zhu\u2019s DNA makeup is built from genetic letters already optimized by eons of evolutionary pressure. It\u2019s [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,385,412],"tags":[],"class_list":["post-146847","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-evolution","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/146847","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=146847"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/146847\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=146847"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=146847"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=146847"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}