{"id":146787,"date":"2022-09-22T01:02:19","date_gmt":"2022-09-22T06:02:19","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/09\/new-method-allows-scientists-to-determine-all-the-molecules-present-in-the-lysosomes-of-mice"},"modified":"2022-09-22T01:02:19","modified_gmt":"2022-09-22T06:02:19","slug":"new-method-allows-scientists-to-determine-all-the-molecules-present-in-the-lysosomes-of-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/09\/new-method-allows-scientists-to-determine-all-the-molecules-present-in-the-lysosomes-of-mice","title":{"rendered":"New method allows scientists to determine all the molecules present in the lysosomes of mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-method-allows-scientists-to-determine-all-the-molecules-present-in-the-lysosomes-of-mice3.jpg\"><\/a><\/p>\n<p>Small but mighty, lysosomes play a surprisingly important role in cells despite their diminutive size. Making up only 1\u20133% of the cell by volume, these small sacs are the cell\u2019s recycling centers, home to enzymes that break down unneeded molecules into small pieces that can then be reassembled to form new ones. Lysosomal dysfunction can lead to a variety of neurodegenerative or other diseases, but without ways to better study the inner contents of lysosomes, the exact molecules involved in diseases\u2014and therefore new drugs to target them\u2014remain elusive.<\/p>\n<p>A new method, reported in <i>Nature<\/i> on Sept. 21, allows scientists to determine all the molecules present in the lysosomes of any cell in mice. Studying the contents of these molecular recycling centers could help researchers learn how the improper degradation of cellular materials leads to certain diseases. Led by Stanford University\u2019s Monther Abu-Remaileh, institute scholar at Sarafan ChEM-H, the study\u2019s team also learned more about the cause for a currently untreatable neurodegenerative <a href=\"https:\/\/phys.org\/tags\/disease\/\" rel=\"tag\" class=\"\">disease<\/a> known as Batten disease, information that could lead to new therapies.<\/p>\n<p>\u201cLysosomes are fascinating both fundamentally and clinically: they supply the rest of the cell with nutrients, but we don\u2019t always know how and when they supply them, and they are the places where many diseases, especially those that affect the brain, start,\u201d said Abu-Remaileh, who is an assistant professor of chemical engineering and of genetics.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Small but mighty, lysosomes play a surprisingly important role in cells despite their diminutive size. Making up only 1\u20133% of the cell by volume, these small sacs are the cell\u2019s recycling centers, home to enzymes that break down unneeded molecules into small pieces that can then be reassembled to form new ones. Lysosomal dysfunction can [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,19,412,47],"tags":[],"class_list":["post-146787","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-chemistry","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/146787","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=146787"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/146787\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=146787"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=146787"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=146787"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}