{"id":146553,"date":"2022-09-16T23:24:08","date_gmt":"2022-09-17T04:24:08","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/09\/intellia-says-crispr-treatment-safely-corrects-dna-of-six-patients-with-rare-disease"},"modified":"2022-09-16T23:24:08","modified_gmt":"2022-09-17T04:24:08","slug":"intellia-says-crispr-treatment-safely-corrects-dna-of-six-patients-with-rare-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/09\/intellia-says-crispr-treatment-safely-corrects-dna-of-six-patients-with-rare-disease","title":{"rendered":"Intellia says CRISPR treatment safely corrects DNA of six patients with rare disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/intellia-says-crispr-treatment-safely-corrects-dna-of-six-patients-with-rare-disease2.jpg\"><\/a><\/p>\n<p>Intellia Therapeutics said Friday the first six patients to receive its CRISPR-based treatment for a genetic swelling disorder have safely had small, corrective changes made to dysfunctional DNA inside their liver cells.<\/p>\n<p>Preliminary results from the study \u2014 just the second to show that CRISPR-based gene editing can be delivered systemically and performed in vivo, or inside the body \u2014 found that the treatment, NTLA-2002, reduced levels of the disease-causing protein, kallikrein, by 65% and 92% in the low-and high-dose cohort, respectively. In the low-dose group, the one-time infusion also reduced by 91% the painful swelling \u201cattacks\u201d commonly experienced by patients with a rare condition called hereditary angioedema, or HAE. Participants in the high-dose group have not yet completed the 16-week observation period.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Intellia Therapeutics said Friday the first six patients to receive its CRISPR-based treatment for a genetic swelling disorder have safely had small, corrective changes made to dysfunctional DNA inside their liver cells. Preliminary results from the study \u2014 just the second to show that CRISPR-based gene editing can be delivered systemically and performed in vivo, [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412],"tags":[],"class_list":["post-146553","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/146553","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=146553"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/146553\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=146553"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=146553"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=146553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}