{"id":146360,"date":"2022-09-13T21:23:12","date_gmt":"2022-09-14T02:23:12","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/09\/association-of-covid-19-with-new-onset-alzheimers-disease"},"modified":"2022-09-13T21:23:12","modified_gmt":"2022-09-14T02:23:12","slug":"association-of-covid-19-with-new-onset-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/09\/association-of-covid-19-with-new-onset-alzheimers-disease","title":{"rendered":"Association of COVID-19 with New-Onset Alzheimer\u2019s Disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/association-of-covid-19-with-new-onset-alzheimers-disease.jpg\"><\/a><\/p>\n<p>The study population comprised 6,245,282 older adults (age \u226565 years) who had medical encounters with healthcare organizations between 2\/2\/2020\u20135\/30\/2021 and had no prior diagnosis of Alzheimer\u2019s disease. The population was divided into two cohorts: 1) COVID-19 cohort (<i>n<\/i> = 410,748)\u2014 contracted COVID-19 between 2\/2\/2020\u20135\/30\/2021; 2) non-COVID-19 cohort (<i>n<\/i> = 5,834,534)\u2014 had no documented COVID-19 but had medical encounters with healthcare organizations between 2\/2\/2020\u20135\/30\/2021. The status of Alzheimer\u2019s disease and COVID-19 were based on the International Classification of Diseases (ICD-10) diagnosis codes and laboratory tests (details in the Supplementary Material).<\/p>\n<p>We examined risks for new diagnosis of Alzheimer\u2019s disease in COVID-19 and non-COVID-19 cohorts in all older adults, three age groups (65\u201374, 75\u201384, \u226585), and three racial\/ethnic groups (Black, White, and Hispanic). Cohorts were propensity-score matched (1:1 using a nearest neighbor greedy matching) for demographics, adverse socioeconomical determinants of health including problems with education, occupational exposure, physical, social and psychosocial environment, and known risk factors for Alzheimer\u2019s disease [13] (details in the Supplementary Material). Kaplan-Meier analysis was used to estimate the probability of new diagnosis of Alzheimer\u2019s disease within 360 days after the COVID-19 diagnosis. Cox\u2019s proportional hazards model was used to compare matched cohorts using hazard ratios and 95% confidence intervals. All statistical tests were conducted within the TriNetX Advanced Analytics Platform at significance set at p &lt; 0.05 (2-sided).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The study population comprised 6,245,282 older adults (age \u226565 years) who had medical encounters with healthcare organizations between 2\/2\/2020\u20135\/30\/2021 and had no prior diagnosis of Alzheimer\u2019s disease. The population was divided into two cohorts: 1) COVID-19 cohort (n = 410,748)\u2014 contracted COVID-19 between 2\/2\/2020\u20135\/30\/2021; 2) non-COVID-19 cohort (n = 5,834,534)\u2014 had no documented COVID-19 but [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,32,1495,47],"tags":[],"class_list":["post-146360","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-education","category-health","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/146360","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=146360"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/146360\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=146360"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=146360"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=146360"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}