{"id":145939,"date":"2022-09-08T19:24:26","date_gmt":"2022-09-09T00:24:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/09\/structural-brain-alterations-associated-with-suicidal-thoughts-and-behaviors-in-young-people-results-from-21-international-studies-from-the-enigma-suicidal-thoughts-and-behaviours-consortium"},"modified":"2022-09-08T19:24:26","modified_gmt":"2022-09-09T00:24:26","slug":"structural-brain-alterations-associated-with-suicidal-thoughts-and-behaviors-in-young-people-results-from-21-international-studies-from-the-enigma-suicidal-thoughts-and-behaviours-consortium","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/09\/structural-brain-alterations-associated-with-suicidal-thoughts-and-behaviors-in-young-people-results-from-21-international-studies-from-the-enigma-suicidal-thoughts-and-behaviours-consortium","title":{"rendered":"Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/structural-brain-alterations-associated-with-suicidal-thoughts-and-behaviors-in-young-people-results-from-21-international-studies-from-the-enigma-suicidal-thoughts-and-behaviours-consortium.jpg\"><\/a><\/p>\n<p>Suicide is the second leading cause of death for young people aged between 15 and 29 [<a data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 1\" title=\"World Health Organization. Suicide in the world&mdash;Global Health Estimates. 2019.\" href=\"https:\/\/www.nature.com\/articles\/s41380-022-01734-0#ref-CR1\" id=\"ref-link-section-d82546579e3035\">1<\/a>]. Suicidal thoughts and behaviors (STBs) typically emerge during adolescence [<a data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 2\" title=\"Hawton K, Saunders KEA, O\u2019Connor RC. Self-harm and suicide in adolescents. Lancet. 2012;379:2373&ndash;82.\" href=\"https:\/\/www.nature.com\/articles\/s41380-022-01734-0#ref-CR2\" id=\"ref-link-section-d82546579e3038\">2<\/a>]. It has been estimated that between 11 and 29% of adolescents report suicidal ideation (suicidal thoughts), and 2\u201310% of adolescents attempted suicide in the past year [<a data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 3\" title=\"Nock MK, Borges G, Bromet EJ, Cha CB, Kessler RC, Lee S. Suicide and suicidal behavior. Epidemiol Rev. 2008;30:133&ndash;54.\" href=\"https:\/\/www.nature.com\/articles\/s41380-022-01734-0#ref-CR3\" id=\"ref-link-section-d82546579e3041\">3<\/a>]. Unfortunately, the number of suicide attempts among children and adolescents has continued to increase sharply despite national and international prevention efforts [<a data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 4\" title=\"Wang J, Sumner SA, Simon TR, Crosby AE, Annor FB, Gaylor E, et al. Trends in the incidence and lethality of suicidal acts in the United States, 2006 to 2015. JAMA Psychiatry. 2020;77:684&ndash;93.\" href=\"https:\/\/www.nature.com\/articles\/s41380-022-01734-0#ref-CR4\" id=\"ref-link-section-d82546579e3044\">4<\/a>].<\/p>\n<p>To improve targeting of prevention and intervention efforts and thereby reduce the number of deaths by suicide in this age group, we must increase our understanding of the mechanisms underlying both suicidal thoughts and suicidal behaviors (including suicide attempts) in young people. Neuroimaging, including Magnetic Resonance Imaging (MRI), is a useful tool with which to identify biological risk markers for STBs in vivo and non-invasively. Many neuroimaging studies have been published examining the neural substrates of STBs in the past 20 years, but few have focused on STBs in youth (for a review, see [5]). Although several of these studies support lower regional brain volumes, particularly in ventral and dorsal prefrontal and also in temporal regions [6,7,8,9] in suicide attempters with mood disorders, negative findings have also been reported [10, 11].<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Suicide is the second leading cause of death for young people aged between 15 and 29 [1]. Suicidal thoughts and behaviors (STBs) typically emerge during adolescence [2]. It has been estimated that between 11 and 29% of adolescents report suicidal ideation (suicidal thoughts), and 2\u201310% of adolescents attempted suicide in the past year [3]. Unfortunately, [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-145939","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/145939","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=145939"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/145939\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=145939"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=145939"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=145939"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}