{"id":144972,"date":"2022-08-27T16:24:20","date_gmt":"2022-08-27T21:24:20","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/08\/researchers-engineer-first-sustainable-chromosome-changes-in-mice"},"modified":"2022-08-27T16:24:20","modified_gmt":"2022-08-27T21:24:20","slug":"researchers-engineer-first-sustainable-chromosome-changes-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/08\/researchers-engineer-first-sustainable-chromosome-changes-in-mice","title":{"rendered":"Researchers engineer first sustainable chromosome changes in mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-engineer-first-sustainable-chromosome-changes-in-mice2.jpg\"><\/a><\/p>\n<p>This finding \u201cproved\u201d the significance of chromosomal rearrangement, a crucial evolutionary indicator of the emergence of a new species.<\/p>\n<p>Researchers from the Chinese Academy of <i>Science<\/i>s (CAS) claim to have found a novel technique for programmable chromosome fusion successfully producing mice with genetic changes \u201cthat occur on a million-year evolutionary scale\u201d in the laboratory.<\/p>\n<p>The findings could shed light on how chromosome rearrangements\u2014the tidy packages of organized genes provided in equal numbers by each parent, which align and trade or blend traits to produce offspring\u2014influence evolution, reported Phys.org on Thursday.<\/p>\n<hr>\n<p>Evolutionary chromosomal changes may take a million years in nature, but researchers are now reporting a novel technique enabling programmable chromosome fusion that has successfully produced mice with genetic changes that occur on a million-year evolutionary scale in the laboratory. The result may provide critical insights into how rearrangements of chromosomes\u2014the tidy packages of organized genes, provided in equal number from each parent, which align and trade or blend traits to produce offspring\u2014influence evolution.<\/p>\n<p>In results published today in <i>Science<\/i>, the researchers reveal that chromosome-level engineering can be achieved in mammals, and they successfully derived a laboratory house mouse with novel and sustainable karyotype, providing critical insight into how <a href=\"https:\/\/phys.org\/tags\/chromosomal+rearrangements\/\" rel=\"tag\" class=\"\">chromosomal rearrangements<\/a> may influence evolution.<\/p>\n<p>\u201cThe laboratory house mouse has maintained a standard 40-chromosome karyotype\u2014or the full picture of an organism\u2019s chromosomes\u2014after more than 100 years of artificial breeding,\u201d said co-first author Li Zhikun, researcher in the Chinese Academy of <i>Science<\/i>s (CAS) Institute of Zoology and the State Key Laboratory of Stem Cell and Reproductive Biology. \u201cOver longer time scales, however, karyotype changes caused by chromosome rearrangements are common. Rodents have 3.2 to 3.5 rearrangements per million years, whereas primates have 1.6.\u201d<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2022\/08\/researchers-engineer-first-sustainable-chromosome-changes-in-mice\">Continue reading \u201cResearchers engineer first sustainable chromosome changes in mice\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This finding \u201cproved\u201d the significance of chromosomal rearrangement, a crucial evolutionary indicator of the emergence of a new species. Researchers from the Chinese Academy of Sciences (CAS) claim to have found a novel technique for programmable chromosome fusion successfully producing mice with genetic changes \u201cthat occur on a million-year evolutionary scale\u201d in the laboratory. The [\u2026]<\/p>\n","protected":false},"author":578,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,385,412],"tags":[],"class_list":["post-144972","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-evolution","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/144972","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/578"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=144972"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/144972\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=144972"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=144972"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=144972"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}