{"id":143441,"date":"2022-08-02T18:28:41","date_gmt":"2022-08-02T23:28:41","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/08\/distinct-toll%e2%80%90like-receptor-signaling-in-the-salamander-response-to-tissue-damage"},"modified":"2022-08-02T18:28:41","modified_gmt":"2022-08-02T23:28:41","slug":"distinct-toll%e2%80%90like-receptor-signaling-in-the-salamander-response-to-tissue-damage","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/08\/distinct-toll%e2%80%90like-receptor-signaling-in-the-salamander-response-to-tissue-damage","title":{"rendered":"Distinct toll\u2010like receptor signaling in the salamander response to tissue damage"},"content":{"rendered":"<p><a class=\"blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/distinct-tolle28090like-receptor-signaling-in-the-salamander-response-to-tissue-damage2.jpg\"><\/a><\/p>\n<p>Circa 2021 This article states that humans have possibly an untapped regeneration ability and they may have found it in mice.<\/p>\n<hr>\n<p>Using new phospho-flow cytometry techniques to measure signaling in individual cell subsets we compared mouse to salamander inflammation. These studies demonstrated evolutionarily conserved responses to PAMP ligands through toll-like receptors (TLRs) but identified key differences in response to DAMP ligands. Co-exposure of macrophages to DAMPs\/PAMPs suppressed MAPK signaling in mammals, but not salamanders, which activate sustained MAPK stimulation in the presence of endogenous DAMPS.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Circa 2021 This article states that humans have possibly an untapped regeneration ability and they may have found it in mice. Using new phospho-flow cytometry techniques to measure signaling in individual cell subsets we compared mouse to salamander inflammation. These studies demonstrated evolutionarily conserved responses to PAMP ligands through toll-like receptors (TLRs) but identified key [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-143441","post","type-post","status-publish","format-standard","hentry","category-biological"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/143441","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=143441"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/143441\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=143441"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=143441"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=143441"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}