{"id":141901,"date":"2022-07-09T01:23:41","date_gmt":"2022-07-09T06:23:41","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/07\/alzheimers-disease-biomarkers-can-predict-postoperative-delirium"},"modified":"2022-07-09T01:23:41","modified_gmt":"2022-07-09T06:23:41","slug":"alzheimers-disease-biomarkers-can-predict-postoperative-delirium","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/07\/alzheimers-disease-biomarkers-can-predict-postoperative-delirium","title":{"rendered":"Alzheimer\u2019s disease biomarkers can predict postoperative delirium"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/alzheimers-disease-biomarkers-can-predict-postoperative-delirium2.jpg\"><\/a><\/p>\n<p>Clinical studies have demonstrated a strong association between Alzheimer\u2019s disease (AD) and delirium. A change to the Tau protein, which can lead to the formation of tangles in brain, is one of the hallmarks of AD pathology, and Tau phosphorylation at threonine 217 (Tau-PT217) and threonine 181 (Tau-PT181) are new plasma biomarkers that can detect early-stage AD. A clinical study led by investigators at Massachusetts General Hospital (MGH) has shown that plasma Tau-PT217 and Tau-PT181 are associated with incidence and severity of postoperative delirium. The findings are published in Annals of Surgery.<\/p>\n<p>Early studies from the same research group at MGH have shown that the ratio of beta amyloid (which causes AD\u2019s signature plaques) to Tau in cerebrospinal fluid is associated with <a href=\"https:\/\/medicalxpress.com\/tags\/postoperative+delirium\/\" rel=\"tag\" class=\"\">postoperative delirium<\/a>. Recent studies in other labs have reported that plasma Tau-PT181 concentration distinguishes AD dementia from other neurological disorders. Plasma levels of Tau-PT217 are associated with the changes in <a href=\"https:\/\/medicalxpress.com\/tags\/cerebrospinal+fluid\/\" rel=\"tag\" class=\"\">cerebrospinal fluid<\/a> levels of Tau-PT217 and AD development.<\/p>\n<p>In this current study, the team at MGH developed a novel method to measure Tau-PT217 and Tau-PT181 concentrations in plasma of patients, called nanoneedle technology, in collaboration with NanoMosaic (Woburn, MA). \u201cThe nanoneedle technology is ultrasensitive, requires a small volume, and can measure low concentrations of molecules, including Tau-PT217 and Tau-PT181,\u201d says lead author Feng Liang, MD, Ph.D., in the Department of Anesthesia, Critical Care and Pain Medicine at MGH. \u201cMore than 20,000 nanoneedles are integrated on a silicon substrate assigned to detect one analyte. Each nanoneedle is a single molecule biosensor functionalized with antibodies,\u201d says Liang.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Clinical studies have demonstrated a strong association between Alzheimer\u2019s disease (AD) and delirium. A change to the Tau protein, which can lead to the formation of tangles in brain, is one of the hallmarks of AD pathology, and Tau phosphorylation at threonine 217 (Tau-PT217) and threonine 181 (Tau-PT181) are new plasma biomarkers that can detect [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-141901","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/141901","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=141901"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/141901\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=141901"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=141901"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=141901"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}