{"id":141499,"date":"2022-07-01T14:24:37","date_gmt":"2022-07-01T19:24:37","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/07\/experimental-drug-reverses-synaptic-loss-in-mouse-models-of-alzheimers"},"modified":"2022-07-01T14:24:37","modified_gmt":"2022-07-01T19:24:37","slug":"experimental-drug-reverses-synaptic-loss-in-mouse-models-of-alzheimers","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/07\/experimental-drug-reverses-synaptic-loss-in-mouse-models-of-alzheimers","title":{"rendered":"Experimental drug reverses synaptic loss in mouse models of Alzheimer\u2019s"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/experimental-drug-reverses-synaptic-loss-in-mouse-models-of-alzheimers2.jpg\"><\/a><\/p>\n<p>An experimental drug restored brain synapses in two mouse models of Alzheimer\u2019s disease, raising hopes that it could help revive cognitive function in human dementia patients, Yale University researchers report June 1 in the journal Science Translational Medicine.<\/p>\n<p>While much research in Alzheimer\u2019s has centered on reducing levels of beta-amyloid plaque in the brain that is a hallmark of the <a href=\"https:\/\/medicalxpress.com\/tags\/disease\/\" rel=\"tag\" class=\"\">disease<\/a>, recent studies have suggested that immune system response in the brain also plays a role in <a href=\"https:\/\/medicalxpress.com\/tags\/memory+loss\/\" rel=\"tag\" class=\"\">memory loss<\/a> in patients.<\/p>\n<p>Some scientists now believe that cognitive decline in Alzheimer\u2019s patients results from a loss of synaptic connections between neurons caused by a steady accumulation of beta-amyloid protein in the brain which in turn unleashes a chronic immune system response to the intruder. The end stages of the disease lead to the death of neurons.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An experimental drug restored brain synapses in two mouse models of Alzheimer\u2019s disease, raising hopes that it could help revive cognitive function in human dementia patients, Yale University researchers report June 1 in the journal Science Translational Medicine. While much research in Alzheimer\u2019s has centered on reducing levels of beta-amyloid plaque in the brain that [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-141499","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/141499","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=141499"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/141499\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=141499"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=141499"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=141499"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}