{"id":141370,"date":"2022-06-30T02:02:56","date_gmt":"2022-06-30T07:02:56","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/06\/new-health-research-suggests-novel-combination-therapy-for-triple-negative-breast-cancer"},"modified":"2022-06-30T02:02:56","modified_gmt":"2022-06-30T07:02:56","slug":"new-health-research-suggests-novel-combination-therapy-for-triple-negative-breast-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/06\/new-health-research-suggests-novel-combination-therapy-for-triple-negative-breast-cancer","title":{"rendered":"New health research suggests novel combination therapy for triple-negative breast cancer"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-health-research-suggests-novel-combination-therapy-for-triple-negative-breast-cancer.jpg\"><\/a><\/p>\n<p>Research led by Suresh Alahari, Ph.D., Professor of Biochemistry at LSU Health New Orleans schools of Medicine and Graduate Studies, suggests a combination of drugs already approved by the FDA for other cancers may be effective in treating chemo-resistant triple-negative breast cancer. The results are published in Molecular Cancer.<\/p>\n<p>Triple-negative breast cancer (TNBC) tumors lack estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 (HER2). A subtype representing 12\u201355% of <a href=\"https:\/\/medicalxpress.com\/tags\/triple-negative+breast+cancer\/\" rel=\"tag\" class=\"\">triple-negative breast cancer<\/a> tumors has androgen receptors (AR). Since <a href=\"https:\/\/medicalxpress.com\/tags\/androgen+receptors\/\" rel=\"tag\" class=\"\">androgen receptors<\/a> stimulate tumor cell progression in estrogen receptor-negative breast cancers, they have become a target of triple-negative breast cancer therapy. As well, since a substantial number of patients with triple-negative breast cancer develop resistance to paclitaxel, the FDA-approved chemotherapeutic agent for triple-negative breast cancer, new therapeutic approaches are needed.<\/p>\n<p>Working in a mouse model and tissue from patients with triple-negative breast cancer, the research team screened 133 FDA-approved drugs that have a therapeutic effect against androgen receptor cells. They found that ceritinib, an FDA-approved drug for lung cancers, efficiently inhibited the growth of androgen receptor triple-negative breast cancer cells. To improve the response, they also selected enzalutamide, an FDA-approved androgen receptor antagonist for prostate cancer treatment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research led by Suresh Alahari, Ph.D., Professor of Biochemistry at LSU Health New Orleans schools of Medicine and Graduate Studies, suggests a combination of drugs already approved by the FDA for other cancers may be effective in treating chemo-resistant triple-negative breast cancer. The results are published in Molecular Cancer. Triple-negative breast cancer (TNBC) tumors lack [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1498,11,1495],"tags":[],"class_list":["post-141370","post","type-post","status-publish","format-standard","hentry","category-augmented-reality","category-biotech-medical","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/141370","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=141370"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/141370\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=141370"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=141370"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=141370"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}