{"id":141242,"date":"2022-06-28T03:08:02","date_gmt":"2022-06-28T08:08:02","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/06\/three-kids-are-thriving-after-kidney-transplants-with-no-immunosuppressants"},"modified":"2022-06-28T03:08:02","modified_gmt":"2022-06-28T08:08:02","slug":"three-kids-are-thriving-after-kidney-transplants-with-no-immunosuppressants","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/06\/three-kids-are-thriving-after-kidney-transplants-with-no-immunosuppressants","title":{"rendered":"Three Kids Are Thriving After Kidney Transplants With No Immunosuppressants"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/three-kids-are-thriving-after-kidney-transplants-with-no-immunosuppressants2.jpg\"><\/a><\/p>\n<p>Our bodies can\u2019t plug-and-play organs like replacement computer parts. The first rule of organ transplant is that the donor organs need to \u201cmatch\u201d with the host to avoid rejection. That is, the protein molecules that help the body discriminate between self and other need to be similar\u2014a trait common (but not guaranteed) among members of the same family.<\/p>\n<p>The key for getting an organ to \u201ctake\u201d is reducing destructive immune attacks\u2014the holy grail in transplantation. One idea is to genetically engineer the transplanted organ so that it immunologically \u201cfits\u201d better with the recipient. Another idea is to look beyond the organ itself to the source of rejection: haemopoietic stem cells, nestled inside the bone marrow, that produce blood and immune cells.<\/p>\n<p>DISOT\u2019s theory is simple but clever: swap out the recipient\u2019s immune system with the donor\u2019s, then <a href=\"https:\/\/singularityhub.com\/2022\/01\/25\/after-first-pig-to-human-organ-transplant-scientists-aim-to-make-it-routine\/\">transplant<\/a> the organ. The recipient\u2019s bone marrow is destroyed, but quickly repopulates with the donor\u2019s stem cells. Once the new immune system takes over, the organ goes in.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our bodies can\u2019t plug-and-play organs like replacement computer parts. The first rule of organ transplant is that the donor organs need to \u201cmatch\u201d with the host to avoid rejection. That is, the protein molecules that help the body discriminate between self and other need to be similar\u2014a trait common (but not guaranteed) among members of [\u2026]<\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1523,412],"tags":[],"class_list":["post-141242","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-computing","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/141242","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=141242"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/141242\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=141242"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=141242"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=141242"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}