{"id":141237,"date":"2022-06-28T03:06:26","date_gmt":"2022-06-28T08:06:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/06\/in-its-greatest-biology-feat-yet-ai-unlocks-the-complex-proteins-guarding-our-dna"},"modified":"2022-06-28T03:06:26","modified_gmt":"2022-06-28T08:06:26","slug":"in-its-greatest-biology-feat-yet-ai-unlocks-the-complex-proteins-guarding-our-dna","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/06\/in-its-greatest-biology-feat-yet-ai-unlocks-the-complex-proteins-guarding-our-dna","title":{"rendered":"In Its Greatest Biology Feat Yet, AI Unlocks the Complex Proteins Guarding Our DNA"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/3GiN6FlsN4Y?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Yet when faced with enormous protein complexes, AI faltered. Until now. In a mind-bending feat, <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abm9506\">a new algorithm<\/a> deciphered the structure at the heart of inheritance\u2014a massive complex of roughly 1,000 proteins that helps channel DNA instructions to the rest of the cell. The AI model is built on AlphaFold by DeepMind and RoseTTAfold from Dr. David Baker\u2019s lab at the University of Washington, which were both released to the public to further experiment on.<\/p>\n<p>Our genes are housed in a planet-like structure, dubbed the nucleus, for protection. The nucleus is a high-security castle: only specific molecules are allowed in and out to deliver DNA instructions to the outside world\u2014for example, to protein-making factories in the cell that translate genetic instructions into proteins.<\/p>\n<p>At the heart of regulating this traffic are nuclear pore complexes, or NPCs (wink to gamers). They\u2019re like extremely intricate drawbridges that strictly monitor the ins and outs of molecular messengers. In biology textbooks, NPCs often look like thousands of cartoonish potholes dotted on a globe. In reality, each NPC is a massively complex, donut-shaped architectural wonder, and one of the largest protein complexes in our bodies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yet when faced with enormous protein complexes, AI faltered. Until now. In a mind-bending feat, a new algorithm deciphered the structure at the heart of inheritance\u2014a massive complex of roughly 1,000 proteins that helps channel DNA instructions to the rest of the cell. The AI model is built on AlphaFold by DeepMind and RoseTTAfold from [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,41,6,1492],"tags":[],"class_list":["post-141237","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-information-science","category-robotics-ai","category-security"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/141237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=141237"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/141237\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=141237"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=141237"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=141237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}