{"id":140227,"date":"2022-06-07T02:22:22","date_gmt":"2022-06-07T07:22:22","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/06\/drug-combination-shows-promise-against-cancers-death-star-protein"},"modified":"2022-06-07T02:22:22","modified_gmt":"2022-06-07T07:22:22","slug":"drug-combination-shows-promise-against-cancers-death-star-protein","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/06\/drug-combination-shows-promise-against-cancers-death-star-protein","title":{"rendered":"Drug combination shows promise against cancer\u2019s \u2018death star\u2019 protein"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/drug-combination-shows-promise-against-cancers-death-star-protein3.jpg\"><\/a><\/p>\n<p>A drug combination targeting multiple mutant versions of cancer\u2019s \u201cdeath star\u201d protein has shown promise in a small, early-phase clinical trial for some patients with advanced lung, ovarian and thyroid cancer.<\/p>\n<p>The two\u2013<a href=\"https:\/\/medicalxpress.com\/tags\/drug+combination\/\" rel=\"tag\" class=\"\">drug combination<\/a> was effective against <a href=\"https:\/\/medicalxpress.com\/tags\/advanced+cancers\/\" rel=\"tag\" class=\"\">advanced cancers<\/a> with a range of mutations to the KRAS gene\u2014dubbed the \u201cdeath star\u201d because its protein drives one in four cancers and has a largely impenetrable, drug-resistant surface.<\/p>\n<p>The phase I trial tested the drugs VS-6766 and everolimus in 30 patients with a range of mutations to KRAS\u2014including 11 with highly advanced, <a href=\"https:\/\/medicalxpress.com\/tags\/non-small+cell+lung+cancer\/\" rel=\"tag\" class=\"\">non-small cell lung cancer<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A drug combination targeting multiple mutant versions of cancer\u2019s \u201cdeath star\u201d protein has shown promise in a small, early-phase clinical trial for some patients with advanced lung, ovarian and thyroid cancer. The two\u2013drug combination was effective against advanced cancers with a range of mutations to the KRAS gene\u2014dubbed the \u201cdeath star\u201d because its protein drives [\u2026]<\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-140227","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/140227","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=140227"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/140227\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=140227"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=140227"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=140227"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}