{"id":139876,"date":"2022-05-27T20:22:31","date_gmt":"2022-05-28T01:22:31","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/05\/brain-on-a-chip-technology-advances-toward-a-new-form-of-drug-screening"},"modified":"2022-05-27T20:22:31","modified_gmt":"2022-05-28T01:22:31","slug":"brain-on-a-chip-technology-advances-toward-a-new-form-of-drug-screening","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/05\/brain-on-a-chip-technology-advances-toward-a-new-form-of-drug-screening","title":{"rendered":"\u2018Brain-on-a-Chip\u2019 Technology Advances Toward a New Form of Drug Screening"},"content":{"rendered":"

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The Stem Cell Reports paper demonstrated the capability to grow and differentiate cortical neurons \u2014 known to be responsible for a majority of higher brain function \u2014 into fully mature and functional cells.<\/p>\n

These neurons were then incorporated into a circuit functioning as a simulated system, where the researchers were able to induce long-term potentiation (LTP). LTP \u2014 which allows for memory formation \u2014 is a key phenomenon in the study of cognition, and one that has mostly evaded direct observation in human models.<\/p>\n

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A UCF researcher\u2019s work to create a \u201cbrain-on-a-chip\u201d aims to improve neurological disorder research by speeding up drug discovery and providing an alternative to animal testing.<\/p>\n

James Hickman \u2014 professor of chemistry<\/a>, biomolecular sciences<\/a> and electrical engineering<\/a> \u2014 recently published some of his latest findings in the journals Stem Cell Reports<\/em><\/a> and Advanced Therapeutics<\/em><\/a>.<\/p>\n

These studies explain advancements in his research group\u2019s efforts to develop the functional neural model otherwise known as a \u201cbrain-on-a-chip.\u201d Such a model could revolutionize neurological research by replicating the pathologies of neurological disorders and rare autoimmune neuropathies, without the need for testing on human or animal subjects.<\/p>\n","protected":false},"excerpt":{"rendered":"

The Stem Cell Reports paper demonstrated the capability to grow and differentiate cortical neurons \u2014 known to be responsible for a majority of higher brain function \u2014 into fully mature and functional cells. These neurons were then incorporated into a circuit functioning as a simulated system, where the researchers were able to induce long-term potentiation [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-139876","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/139876","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=139876"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/139876\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=139876"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=139876"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=139876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}