{"id":138435,"date":"2022-04-22T11:23:11","date_gmt":"2022-04-22T16:23:11","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/04\/largest-study-of-whole-genome-sequencing-data-reveals-treasure-trove-of-clues-about-causes-of-cancer"},"modified":"2022-04-22T11:23:11","modified_gmt":"2022-04-22T16:23:11","slug":"largest-study-of-whole-genome-sequencing-data-reveals-treasure-trove-of-clues-about-causes-of-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/04\/largest-study-of-whole-genome-sequencing-data-reveals-treasure-trove-of-clues-about-causes-of-cancer","title":{"rendered":"Largest study of whole genome sequencing data reveals \u2018treasure trove\u2019 of clues about causes of cancer"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/largest-study-of-whole-genome-sequencing-data-reveals-treasure-trove-of-clues-about-causes-of-cancer2.jpg\"><\/a><\/p>\n<p>DNA analysis of thousands of tumors from NHS patients has found a \u2018treasure trove\u2019 of clues about the causes of cancer, with genetic mutations providing a personal history of the damage and repair processes each patient has been through.<\/p>\n<p>In the biggest study of its kind, a team of scientists led by Professor Serena Nik-Zainal from Cambridge University Hospitals (CUH) and University of Cambridge, analyzed the complete genetic make-up or whole-genome sequences of more than 12,000 NHS cancer patients.<\/p>\n<p>Because of the vast amount of data provided by <a href=\"https:\/\/medicalxpress.com\/tags\/whole+genome+sequencing\/\" rel=\"tag\" class=\"\">whole genome sequencing<\/a>, the researchers were able to detect patterns in the DNA of cancer\u2014or \u2018mutational signatures\u2019\u2014that provide clues about whether a patient has had a past exposure to environmental causes of cancer such as smoking or UV light, or has internal, cellular malfunctions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>DNA analysis of thousands of tumors from NHS patients has found a \u2018treasure trove\u2019 of clues about the causes of cancer, with genetic mutations providing a personal history of the damage and repair processes each patient has been through. In the biggest study of its kind, a team of scientists led by Professor Serena Nik-Zainal [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-138435","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/138435","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=138435"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/138435\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=138435"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=138435"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=138435"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}