{"id":138196,"date":"2022-04-16T03:02:47","date_gmt":"2022-04-16T08:02:47","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/04\/key-signaling-pathway-in-immune-cells-could-be-new-alzheimers-target"},"modified":"2022-04-16T03:02:47","modified_gmt":"2022-04-16T08:02:47","slug":"key-signaling-pathway-in-immune-cells-could-be-new-alzheimers-target","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/04\/key-signaling-pathway-in-immune-cells-could-be-new-alzheimers-target","title":{"rendered":"Key Signaling Pathway in Immune Cells Could Be New Alzheimer\u2019s Target"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/key-signaling-pathway-in-immune-cells-could-be-new-alzheimers-target.jpg\"><\/a><\/p>\n<p>Summary: Tau-tangles trigger the inflammatory activation of microglia via the NF-\u03baB pathway. Inhibiting the microglia NF-\u03baB signaling pulled the immune cells out of their inflammatory state and reversed learning and memory problems in tau-based Alzheimer\u2019s mouse models.<\/p>\n<p>Source: Weill Cornell Medicine.<\/p>\n<p>Inhibiting an important signaling pathway in brain-resident immune cells may calm brain inflammation and thereby slow the disease process in Alzheimer\u2019s and some other neurodegenerative diseases, suggests a study by Weill Cornell Medicine investigators.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Tau-tangles trigger the inflammatory activation of microglia via the NF-\u03baB pathway. Inhibiting the microglia NF-\u03baB signaling pulled the immune cells out of their inflammatory state and reversed learning and memory problems in tau-based Alzheimer\u2019s mouse models. Source: Weill Cornell Medicine. Inhibiting an important signaling pathway in brain-resident immune cells may calm brain inflammation and [\u2026]<\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-138196","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/138196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=138196"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/138196\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=138196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=138196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=138196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}