{"id":137823,"date":"2022-04-07T16:22:26","date_gmt":"2022-04-07T21:22:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/04\/scientists-used-cellular-rejuvenation-therapy-to-rewind-aging-in-mice"},"modified":"2022-04-07T16:22:26","modified_gmt":"2022-04-07T21:22:26","slug":"scientists-used-cellular-rejuvenation-therapy-to-rewind-aging-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/04\/scientists-used-cellular-rejuvenation-therapy-to-rewind-aging-in-mice","title":{"rendered":"Scientists Used Cellular Rejuvenation Therapy to Rewind Aging in Mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scientists-used-cellular-rejuvenation-therapy-to-rewind-aging-in-mice2.jpg\"><\/a><\/p>\n<p>At roughly 70 years human age, the mice looked elderly and unremarkable. Yet hidden underneath was a youthful cellular clock, turned back in time based on a Nobel-Prize-winning strategy. It\u2019s also the latest bet for finding the fountain of youth, backed by heavy-hitter anti-aging startups in Silicon Valley.<\/p>\n<p>At the center is partial cellular reprogramming. The technique, a sort of gene therapy, forces cells to make four proteins, collectively dubbed the Yamanaka factors. Like erasers, the factors wipe a cell\u2019s genetic history clean, reverting adult cells\u2014for example, skin cells\u2014to a stem cell-like identity, giving them back the superpower to turn into almost any type of cell.<\/p>\n<p>The process isn\u2019t all-or-nothing. In a twist, scientists recently found that they can use the factors to rewind a cell\u2019s genetic history tape rather than destroying it altogether. And if they stop at the right point, the cell dramatically loses its age, becoming more youthful but retaining its identity. The results <a href=\"https:\/\/www.nature.com\/articles\/d41587-022-00002-4\">spurred a wave of interest<\/a> in moving the therapy to humans, with Calico Life Sciences\u2014a sister company to Google\u2014and Altos Labs, backed by Jeff Bezos, in the race.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>At roughly 70 years human age, the mice looked elderly and unremarkable. Yet hidden underneath was a youthful cellular clock, turned back in time based on a Nobel-Prize-winning strategy. It\u2019s also the latest bet for finding the fountain of youth, backed by heavy-hitter anti-aging startups in Silicon Valley. At the center is partial cellular reprogramming. [\u2026]<\/p>\n","protected":false},"author":367,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269],"tags":[],"class_list":["post-137823","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/137823","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/367"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=137823"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/137823\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=137823"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=137823"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=137823"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}