{"id":137557,"date":"2022-03-31T19:02:20","date_gmt":"2022-04-01T00:02:20","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/03\/stat1-gain-of-function-type-1-diabetes-and-reversal-with-jak-inhibition"},"modified":"2022-03-31T19:02:20","modified_gmt":"2022-04-01T00:02:20","slug":"stat1-gain-of-function-type-1-diabetes-and-reversal-with-jak-inhibition","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/03\/stat1-gain-of-function-type-1-diabetes-and-reversal-with-jak-inhibition","title":{"rendered":"STAT1 Gain of Function, Type 1 Diabetes, and Reversal with JAK Inhibition"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/stat1-gain-of-function-type-1-diabetes-and-reversal-with-jak-inhibition.jpg\"><\/a><\/p>\n<p>Type 1 diabetes is caused by insulin deficiency resulting from immune-mediated destruction of pancreatic beta cells. Its cause is multifactorial, with complex genetic factors and a strong influence of certain HLA types that probably indicates T-cell-mediated disease.1 Despite attempts to halt the autoimmune destruction of the pancreatic islet at disease onset with immunotherapeutic approaches, 1 recovery of pancreatic beta-cell function remains a challenge because type 1 diabetes is not reversible, even early in the disease.<\/p>\n<hr>\n<p>Correspondence from The New England Journal of Medicine \u2014 STAT1 Gain of Function, Type 1 Diabetes, and Reversal with JAK Inhibition.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Type 1 diabetes is caused by insulin deficiency resulting from immune-mediated destruction of pancreatic beta cells. Its cause is multifactorial, with complex genetic factors and a strong influence of certain HLA types that probably indicates T-cell-mediated disease.1 Despite attempts to halt the autoimmune destruction of the pancreatic islet at disease onset with immunotherapeutic approaches, 1 [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-137557","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/137557","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=137557"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/137557\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=137557"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=137557"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=137557"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}