{"id":136711,"date":"2022-03-11T15:59:08","date_gmt":"2022-03-11T23:59:08","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2022\/03\/a-dna-oracle-for-predicting-the-future-evolution-of-gene-regulation"},"modified":"2022-03-11T15:59:08","modified_gmt":"2022-03-11T23:59:08","slug":"a-dna-oracle-for-predicting-the-future-evolution-of-gene-regulation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2022\/03\/a-dna-oracle-for-predicting-the-future-evolution-of-gene-regulation","title":{"rendered":"A DNA \u201cOracle\u201d for Predicting the Future Evolution of Gene Regulation"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-dna-oracle-for-predicting-the-future-evolution-of-gene-regulation3.jpg\"><\/a><\/p>\n<p><strong>Researchers created a mathematical framework to examine the genome and detect signatures of natural selection, deciphering the evolutionary past and future of non-coding DNA.<\/strong><\/p>\n<p>Despite the sheer number of genes that each human cell contains, these so-called \u201ccoding\u201d DNA sequences comprise just 1% of our entire genome. The remaining 99% is made up of \u201cnon-coding\u201d DNA \u2014 which, unlike coding DNA, does not carry the instructions to build proteins.<\/p>\n<p>One vital function of this non-coding DNA, also called \u201cregulatory\u201d DNA, is to help turn genes on and off, controlling how much (if any) of a protein is made. Over time, as cells replicate their DNA to grow and divide, mutations often crop up in these non-coding regions \u2014 sometimes tweaking their function and changing the way they control gene expression. Many of these mutations are trivial, and some are even beneficial. Occasionally, though, they can be associated with increased risk of common diseases, such as type 2 diabetes, or more life-threatening ones, including cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers created a mathematical framework to examine the genome and detect signatures of natural selection, deciphering the evolutionary past and future of non-coding DNA. Despite the sheer number of genes that each human cell contains, these so-called \u201ccoding\u201d DNA sequences comprise just 1% of our entire genome. The remaining 99% is made up of \u201cnon-coding\u201d [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,385,412,2229],"tags":[],"class_list":["post-136711","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-evolution","category-genetics","category-mathematics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/136711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=136711"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/136711\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=136711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=136711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=136711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}